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Gene Review

CHST3  -  carbohydrate (chondroitin 6)...

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High impact information on CHST3

  • The developmental expression of the C6ST gene was also found to parallel the developmental down-regulation of both the C6ST activity and the chondroitin 6-sulfate structure [1].
  • In this report, developmental regulation of both the sulfation profile of chondroitin sulfate chains and activities of chondroitin 4-sulfotransferase (C4ST) and chondroitin 6-sulfotransferase (C6ST) were evaluated in embryonic chicken brain [1].
  • Chondroitin 6-sulfotransferase (C6ST) catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to position 6 of the N-acetylgalactosamine residue of chondroitin [2].
  • In this study, we examined the sulfation of sialyl lactosamine oligosaccharides by C6ST [3].
  • These results raised a possibility that C6ST may be one of the candidates involved in the biosynthesis of sulfated sialyl Lewis x ligand for L-selectin [3].


  1. Developmental regulation of the sulfation profile of chondroitin sulfate chains in the chicken embryo brain. Kitagawa, H., Tsutsumi, K., Tone, Y., Sugahara, K. J. Biol. Chem. (1997) [Pubmed]
  2. Molecular cloning and expression of chick chondrocyte chondroitin 6-sulfotransferase. Fukuta, M., Uchimura, K., Nakashima, K., Kato, M., Kimata, K., Shinomura, T., Habuchi, O. J. Biol. Chem. (1995) [Pubmed]
  3. Sulfation of sialyl lactosamine oligosaccharides by chondroitin 6-sulfotransferase. Habuchi, O., Suzuki, Y., Fukuta, M. Glycobiology (1997) [Pubmed]
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