Gene Review:
cmet - CENP-meta
Drosophila melanogaster
Synonyms:
CENP-E, CENP-E meta, CENP-META, CENP-Meta, CENPE, ...
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High impact information on cmet
- P-element-mediated disruption of the CENP-meta gene leads to late larval/pupal stage lethality with incomplete chromosome alignment at metaphase [1].
- Real-time imaging of these mutants with GFP-labeled chromosomes demonstrates that CENP-meta is required for the maintenance of chromosomes at the metaphase plate, demonstrating that the functions required to establish and maintain chromosome congression have distinguishable requirements [1].
- CENP-meta, an essential kinetochore kinesin required for the maintenance of metaphase chromosome alignment in Drosophila [1].
- The 257-kD CENP-meta protein is most similar to the vertebrate kinetochore-associated kinesin-like protein CENP-E, and like CENP-E, is shown to be a component of centromeric/kinetochore regions of Drosophila chromosomes [1].
- However, unlike CENP-E, which leaves the centromere/kinetochore region at the end of anaphase A, the CENP-meta protein remains associated with the centromeric/kinetochore region of the chromosome during all stages of the Drosophila cell cycle [1].
Biological context of cmet
- Complete removal of CENP-meta from the female germline leads to lethality in early embryos resulting from defects in metaphase chromosome alignment [1].
References
- CENP-meta, an essential kinetochore kinesin required for the maintenance of metaphase chromosome alignment in Drosophila. Yucel, J.K., Marszalek, J.D., McIntosh, J.R., Goldstein, L.S., Cleveland, D.W., Philp, A.V. J. Cell Biol. (2000) [Pubmed]
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