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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

POLD3  -  polymerase (DNA-directed), delta 3,...

Bos taurus

 
 
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High impact information on LOC537616

  • The p68 polypeptide was shown to be a PCNA binding protein by overlay methods with biotinylated PCNA [1].
  • These chains are directional and might reflect a mechanism whereby the two different ends of (chains of) the p68 molecules interact with different membranes [2].
  • The calcium-sensitive, membrane-binding annexin, p68, has been crystallized from solutions of polyethylene glycol and ammonium sulfate [2].
  • CONCLUSION: These studies support a central role for MT4-MMP in IL-1-induced cartilage aggrecanolysis and are consistent with the identification of p68 as the aggrecanase that cleaves within the CS2 domain, and of p53 as the aggrecanase that generates G1-NITEGE [3].
  • Addition of either 1.35 mM ManN or 31-500 microM EST blocked IL-1-mediated aggrecanolysis and this was accompanied by nearly complete inhibition of the MT4-MMP increase, the p68 loss and the formation of p53 [3].
 

Analytical, diagnostic and therapeutic context of LOC537616

  • Our electron microscopy and X-ray diffraction data indicate that p68 crystals are tetragonal, in space group P4(1), and have unit cell dimensions of a = b = 68.4 A and c = 209.6 A [2].

References

  1. Evidence that DNA polymerase delta isolated by immunoaffinity chromatography exhibits high-molecular weight characteristics and is associated with the KIAA0039 protein and RPA. Mo, J., Liu, L., Leon, A., Mazloum, N., Lee, M.Y. Biochemistry (2000) [Pubmed]
  2. Microcrystals of the annexin, p68: paracrystal to crystal transition and molecular packing as determined by electron microscopy and image reconstruction. Gabriel, B.L., Taylor, K., Creutz, C.E., Kretsinger, R.H. J. Struct. Biol. (1991) [Pubmed]
  3. Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage. Patwari, P., Gao, G., Lee, J.H., Grodzinsky, A.J., Sandy, J.D. Osteoarthr. Cartil. (2005) [Pubmed]
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