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Gene Review:

Slc5a3 - solute carrier family 5 (inositol...

Mus musculus

Synonyms: AA623876, BF642829, Na(+)/myo-inositol cotransporter, SMIT1, Smit1, ...

McVeigh, K.E. et al., Chauvin, T.R. et al., Berry, G.T. et al.

Berry, Wu, Buccafusca, Ren, Gonzales, Ballard, Golden, Stevens, Greer,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Slc5a3

The Na(+)/myo-inositol cotransporter (SMIT1 or SLC5A3) gene is highly expressed prenatally in the central nervous system and placenta [1].
When Sertoli cells were cultured in a hypertonic medium, there was an increase in the expression of Isyna1 and Slc5a3 [2].
The objective of this study was to evaluate the expression of these genes and the myo-inositol transporter, Slc5a3, within the testis [2].
Slc5a3 expression is upregulated when Sertoli cells are treated with 0.1 mM dibutyryl cAMP [2].
Using fluorescence in situ hybridization, Slc5a3 was localized to the telomeric region of mouse chromosome 16, which is syntenic to human chromosome 21q22 [3].

Biological context of Slc5a3

Murine chromosome 16 telomeric region, homologous with human chromosome 21q22, contains the osmoregulatory Na(+)/myo-inositol cotransporter (SLC5A3) gene [3].

Other interactions of Slc5a3

An increased Slc5a3 copy number may explain the increased levels of myo-inositol in the brains of trisomy 16 mice and the increased rate of transport of myo-inositol into cultured neurons derived from trisomy 16 mice [3].

References

Loss of murine Na+/myo-inositol cotransporter leads to brain myo-inositol depletion and central apnea. Berry, G.T., Wu, S., Buccafusca, R., Ren, J., Gonzales, L.W., Ballard, P.L., Golden, J.A., Stevens, M.J., Greer, J.J. J. Biol. Chem. (2003) [Pubmed]
Characterization of the expression and regulation of genes necessary for myo-inositol biosynthesis and transport in the seminiferous epithelium. Chauvin, T.R., Griswold, M.D. Biol. Reprod. (2004) [Pubmed]
Murine chromosome 16 telomeric region, homologous with human chromosome 21q22, contains the osmoregulatory Na(+)/myo-inositol cotransporter (SLC5A3) gene. McVeigh, K.E., Mallee, J.J., Lucente, A., Barnoski, B.L., Wu, S., Berry, G.T. Cytogenet. Cell Genet. (2000) [Pubmed]

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