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Gene Review

SLC37A1  -  solute carrier family 37 (glucose-6...

Homo sapiens

Synonyms: G-3-P permease, G-3-P transporter, G3PP, Glycerol-3-phosphate permease, Glycerol-3-phosphate transporter, ...
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Disease relevance of SLC37A1


High impact information on SLC37A1

  • Using the x-ray structure of the glycerol 3-phosphate transporter (GlpT), we devised a model for the distantly related oxalate transporter, OxlT [3].
  • In other bacteria, GlpQ hydrolyzes deacylated phospholipids to glycerol-3-phosphate (G3P) while GlpT transports G3P into the cytoplasm [1].
  • Thus SLC37A1 mutations may cause a phenotype similar to GK deficiency [4].
  • 3. Mutation analyses also excluded SLC37A1 as the gene for DFNB10 [4].
  • Comparison of the SLC37A1 cDNA to genomic sequence revealed that the gene encompasses 82 kb, and it is split into 19 coding exons and 7 untranslated exons, which are alternatively spliced in a complex and tissue-specific manner [4].


  1. Glycerol-3-phosphate acquisition in spirochetes: distribution and biological activity of glycerophosphodiester phosphodiesterase (GlpQ) among Borrelia species. Schwan, T.G., Battisti, J.M., Porcella, S.F., Raffel, S.J., Schrumpf, M.E., Fischer, E.R., Carroll, J.A., Stewart, P.E., Rosa, P., Somerville, G.A. J. Bacteriol. (2003) [Pubmed]
  2. A Three-dimensional Model of Human Organic Anion Transporter 1: AROMATIC AMINO ACIDS REQUIRED FOR SUBSTRATE TRANSPORT. Perry, J.L., Dembla-Rajpal, N., Hall, L.A., Pritchard, J.B. J. Biol. Chem. (2006) [Pubmed]
  3. Experimental tests of a homology model for OxlT, the oxalate transporter of Oxalobacter formigenes. Yang, Q., Wang, X., Ye, L., Mentrikoski, M., Mohammadi, E., Kim, Y.M., Maloney, P.C. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  4. Cloning and characterization of a putative human glycerol 3-phosphate permease gene (SLC37A1 or G3PP) on 21q22.3: mutation analysis in two candidate phenotypes, DFNB10 and a glycerol kinase deficiency. Bartoloni, L., Wattenhofer, M., Kudoh, J., Berry, A., Shibuya, K., Kawasaki, K., Wang, J., Asakawa, S., Talior, I., Bonne-Tamir, B., Rossier, C., Michaud, J., McCabe, E.R., Minoshima, S., Shimizu, N., Scott, H.S., Antonarakis, S.E. Genomics (2000) [Pubmed]
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