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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

POLE2  -  polymerase (DNA directed), epsilon 2,...

Homo sapiens

Synonyms: DNA polymerase II subunit 2, DNA polymerase epsilon subunit 2, DNA polymerase epsilon subunit B, DPE2
 
 
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Disease relevance of POLE2

  • The equilibrium binding and dissociation kinetics of the enkephalin dimer bis-(D-Ala2-D-Leu5-enkephalin)-ethylenediamide (designated DPE2) to neuroblastoma glioma NG108-15 cells were investigated and compared with the monomers D-Ala2-D-Leu5-enkephalin (DADL) and D-Ala2-Leu5-enkephalinamide (DALEA) [1].
 

High impact information on POLE2

  • Using fluorescence in situ hybridization, the human pol epsilon p59 locus (DPE2) was assigned to chromosome 14q13-q21 [2].
  • The gene for the small subunit of human DNA polymerase epsilon (POLE2) was localized to chromosome 14q21-q22 by fluorescence in situ hybridization [3].
  • At 25 degrees C, the values of the apparent affinity constant for DPE2, measured to intact and lysed cells and membranes, was 5.0 (+/- 0.09) X 10(9) M-1 for n = 28 experiments, as compared to 0.9 (+/- 0.08) X 10(9) M-1 (n = 16) for DALEA [4].
  • Binding activity of the enkephalin dimer [D-Ala2, Leu5-NH-CH2-]2 (DPE2) to NG108-15 hybrid cells was compared to that of the monomer [D-Ala2, Leu5]enkephalin amide (DALEA) [4].
  • The increased affinity of DPE2 did not revert to that of the monomer DADL by this reduction of binding sites [1].

References

  1. Increased affinity of dimeric enkephalins is not dependent on receptor density. Lutz, R.A., Costa, T., Cruciani, R.A., Jacobson, A.E., Rice, K.C., Burke, T.R., Krumins, S.A., Rodbard, D. Neuropeptides (1985) [Pubmed]
  2. Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon. Li, Y., Asahara, H., Patel, V.S., Zhou, S., Linn, S. J. Biol. Chem. (1997) [Pubmed]
  3. The small subunits of human and mouse DNA polymerase epsilon are homologous to the second largest subunit of the yeast Saccharomyces cerevisiae DNA polymerase epsilon. Jokela, M., Mäkiniemi, M., Lehtonen, S., Szpirer, C., Hellman, U., Syväoja, J.E. Nucleic Acids Res. (1998) [Pubmed]
  4. Comparative studies of the binding of dimeric and monomeric enkephalins to neuroblastoma-glioma NG108-15 cells. Krumins, S.A., Rodbard, D. J. Neurochem. (1985) [Pubmed]
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