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Gene Review

TAF7L  -  TAF7-like RNA polymerase II, TATA box...

Homo sapiens

Synonyms: CT40, Cancer/testis antigen 40, RNA polymerase II TBP-associated factor subunit Q, TAF2Q, TATA box-binding protein-associated factor 50 kDa, ...
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Disease relevance of TAF7L


High impact information on TAF7L


Biological context of TAF7L

  • In order to analyse the involvement of the hTAF7L gene in the aetiology of male infertility, a total of 25 patients with maturation arrest of spermatogenesis have been analysed for the presence of mutations in this gene [1].

Other interactions of TAF7L

  • We further show that TAF3, TAF4 and TAF10 are all strongly expressed in early spermatocytes, but that in contrast to TBP and TAF7L, they are downregulated in haploid cells [2].


  1. The role of the testis-specific gene hTAF7L in the aetiology of male infertility. Stouffs, K., Willems, A., Lissens, W., Tournaye, H., Van Steirteghem, A., Liebaers, I. Mol. Hum. Reprod. (2006) [Pubmed]
  2. The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation. Pointud, J.C., Mengus, G., Brancorsini, S., Monaco, L., Parvinen, M., Sassone-Corsi, P., Davidson, I. J. Cell. Sci. (2003) [Pubmed]
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