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Gene Review:

TAF7L - TAF7-like RNA polymerase II, TATA box...

Homo sapiens

Synonyms: CT40, Cancer/testis antigen 40, RNA polymerase II TBP-associated factor subunit Q, TAF2Q, TATA box-binding protein-associated factor 50 kDa, ...

Pointud, J.C. et al., Stouffs, K. et al.

Stouffs, Willems, Lissens, Tournaye, Van Steirteghem, Liebaers,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of TAF7L

The role of the testis-specific gene hTAF7L in the aetiology of male infertility [1].

High impact information on TAF7L

The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation [2].
TAF7L is expressed through most of the male germ-cell differentiation programme, but its intracellular localisation is dynamically regulated from cytoplasmic in spermatogonia and early spermatocytes to nuclear in late pachytene spermatocytes and haploid round spermatids [2].
The X-linked TAF7L gene is homologous to the autosomal transcription factor TAF7 [1].

Biological context of TAF7L

In order to analyse the involvement of the hTAF7L gene in the aetiology of male infertility, a total of 25 patients with maturation arrest of spermatogenesis have been analysed for the presence of mutations in this gene [1].

Other interactions of TAF7L

We further show that TAF3, TAF4 and TAF10 are all strongly expressed in early spermatocytes, but that in contrast to TBP and TAF7L, they are downregulated in haploid cells [2].

References

The role of the testis-specific gene hTAF7L in the aetiology of male infertility. Stouffs, K., Willems, A., Lissens, W., Tournaye, H., Van Steirteghem, A., Liebaers, I. Mol. Hum. Reprod. (2006) [Pubmed]
The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation. Pointud, J.C., Mengus, G., Brancorsini, S., Monaco, L., Parvinen, M., Sassone-Corsi, P., Davidson, I. J. Cell. Sci. (2003) [Pubmed]

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