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Gene Review

TAF7  -  TAF7 RNA polymerase II, TATA box binding...

Homo sapiens

Synonyms: RNA polymerase II TBP-associated factor subunit F, TAF(II)55, TAF2F, TAFII-55, TAFII55, ...
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Disease relevance of TAF7


High impact information on TAF7


Biological context of TAF7

  • Interaction in vitro correlates with enhanced transactivation function of c-Jun in HEK293 and COS cells in the presence of increasing amounts of TAF7 [6].
  • Taken together, these results reveal a physiological function of TAF7 as a basal regulator for mammalian polyamine transport activity and MGBG-induced apoptosis [1].
  • To uncover the regulatory properties of the general transcription machinery, we have isolated the hTAF(II)55 gene and dissected the regulatory elements and the core promoter responsible for hTAF(II)55 gene expression [7].
  • Surprisingly, the hTAF(II)55 gene has a single uninterrupted open reading frame and is the only intronless general transcription factor identified so far [7].
  • The ptr6(+) gene was found to encode an essential protein of 393 amino acids, which shares significant homology in amino acid sequence with yTAFII67 of budding yeast Saccharomyces cerevisiae and human hTAFII55, a subunit of the general transcription factor complex TFIID [8].

Anatomical context of TAF7

  • TAF7-deficient cells had decreased capacity for polyamine uptake (20% of CHO cells), decreased AP-1 activation, as well as resistance to MGBG-induced apoptosis [1].
  • This provides us with an estimation of the in vivo half-lives of TBP and TAFII55, which were assessed to be less than 20 and 6 hours, respectively, in HeLa cells [9].

Associations of TAF7 with chemical compounds


Physical interactions of TAF7

  • Multiple interactions between hTAFII55 and other TFIID subunits. Requirements for the formation of stable ternary complexes between hTAFII55 and the TATA-binding protein [10].

Regulatory relationships of TAF7


Other interactions of TAF7

  • We further show that purified recombinant TIF1alpha possesses intrinsic kinase activity and that, in addition to autophosphorylation, TIF1alpha selectively phosphorylates the transcription factors TFIIEalpha, TAFII28, and TAFII55 in vitro [11].


  1. TATA-binding protein-associated factor 7 regulates polyamine transport activity and polyamine analog-induced apoptosis. Fukuchi, J., Hiipakka, R.A., Kokontis, J.M., Nishimura, K., Igarashi, K., Liao, S. J. Biol. Chem. (2004) [Pubmed]
  2. Functional characterization of core promoter elements: DPE-specific transcription requires the protein kinase CK2 and the PC4 coactivator. Lewis, B.A., Sims, R.J., Lane, W.S., Reinberg, D. Mol. Cell (2005) [Pubmed]
  3. TAF7: a possible transcription initiation check-point regulator. Gegonne, A., Weissman, J.D., Zhou, M., Brady, J.N., Singer, D.S. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  4. TAFII55 binding to TAFII250 inhibits its acetyltransferase activity. Gegonne, A., Weissman, J.D., Singer, D.S. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  5. Human TAF(II)55 interacts with the vitamin D(3) and thyroid hormone receptors and with derivatives of the retinoid X receptor that have altered transactivation properties. Lavigne, A.C., Mengus, G., Gangloff, Y.G., Wurtz, J.M., Davidson, I. Mol. Cell. Biol. (1999) [Pubmed]
  6. TAF7 (TAFII55) plays a role in the transcription activation by c-Jun. Munz, C., Psichari, E., Mandilis, D., Lavigne, A.C., Spiliotaki, M., Oehler, T., Davidson, I., Tora, L., Angel, P., Pintzas, A. J. Biol. Chem. (2003) [Pubmed]
  7. The intronless and TATA-less human TAF(II)55 gene contains a functional initiator and a downstream promoter element. Zhou, T., Chiang, C.M. J. Biol. Chem. (2001) [Pubmed]
  8. Characterization of the ptr6(+) gene in fission yeast: a possible involvement of a transcriptional coactivator TAF in nucleocytoplasmic transport of mRNA. Shibuya, T., Tsuneyoshi, S., Azad, A.K., Urushiyama, S., Ohshima, Y., Tani, T. Genetics (1999) [Pubmed]
  9. Establishment of stable cell lines expressing potentially toxic proteins by tetracycline-regulated and epitope-tagging methods. Wu, S.Y., Chiang, C.M. BioTechniques (1996) [Pubmed]
  10. Multiple interactions between hTAFII55 and other TFIID subunits. Requirements for the formation of stable ternary complexes between hTAFII55 and the TATA-binding protein. Lavigne, A.C., Mengus, G., May, M., Dubrovskaya, V., Tora, L., Chambon, P., Davidson, I. J. Biol. Chem. (1996) [Pubmed]
  11. The putative cofactor TIF1alpha is a protein kinase that is hyperphosphorylated upon interaction with liganded nuclear receptors. Fraser, R.A., Heard, D.J., Adam, S., Lavigne, A.C., Le Douarin, B., Tora, L., Losson, R., Rochette-Egly, C., Chambon, P. J. Biol. Chem. (1998) [Pubmed]
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