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Gene Review

HES2  -  hes family bHLH transcription factor 2

Homo sapiens

Synonyms: BHLHB40, Class B basic helix-loop-helix protein 40, Hairy and enhancer of split 2, Transcription factor HES-2, bHLHb40
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Disease relevance of HES2


High impact information on HES2

  • Hes2 encodes a mammalian basic helix-loop-helix transcriptional repressor homologous to the products of Drosophila hairy and Enhancer of split [2].
  • Notch1/2/3 and Hes1 were expressed in most GC cell lines as well as normal gastric mucosae, while Hes2/3 were expressed in neither these cell lines nor the normal stomach [3].
  • Identification and characterization of human HES2, HES3, and HES5 genes in silico [1].
  • HES2 gene, encoding a 173-aa protein, was located within human genome sequence AL031848.11 [1].

Anatomical context of HES2

  • METHODS: The hES cell line HES-2 was propagated in Dulbecco's modification of Eagle's medium (DMEM) in the presence of 20% fetal calf serum (FCS) on a mouse embryonic fibroblast feeder layer [4].

Analytical, diagnostic and therapeutic context of HES2

  • The number of beating areas increased up to 12 days after initiation of coculture of HES-2 with END-2 cells [5].


  1. Identification and characterization of human HES2, HES3, and HES5 genes in silico. Katoh, M., Katoh, M. Int. J. Oncol. (2004) [Pubmed]
  2. Structure, chromosomal locus, and promoter of mouse Hes2 gene, a homologue of Drosophila hairy and Enhancer of split. Nishimura, M., Isaka, F., Ishibashi, M., Tomita, K., Tsuda, H., Nakanishi, S., Kageyama, R. Genomics (1998) [Pubmed]
  3. Hath1 up-regulates gastric mucin gene expression in gastric cells. Sekine, A., Akiyama, Y., Yanagihara, K., Yuasa, Y. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  4. Human embryonic stem cells form embryoid bodies containing visceral endoderm-like derivatives. Conley, B.J., Trounson, A.O., Mollard, R. Fetal. Diagn. Ther. (2004) [Pubmed]
  5. Increased cardiomyocyte differentiation from human embryonic stem cells in serum-free cultures. Passier, R., Oostwaard, D.W., Snapper, J., Kloots, J., Hassink, R.J., Kuijk, E., Roelen, B., de la Riviere, A.B., Mummery, C. Stem Cells (2005) [Pubmed]
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