The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

HES5  -  hes family bHLH transcription factor 5

Homo sapiens

Synonyms: BHLHB38, Class B basic helix-loop-helix protein 38, Hairy and enhancer of split 5, Transcription factor HES-5, bHLHb38
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of HES5


High impact information on HES5

  • This function is mediated by the requirement of NFIA for the expression of HES5, a Notch effector [3].
  • A molecular insight of Hes5-dependent inhibition of myelin gene expression: old partners and new players [4].
  • We report here upregulation of myelin gene expression in Hes5-/- mice compared to wild-type siblings and downregulation in overexpressing progenitors [4].
  • Novel mechanisms of Hes5 function in the oligodendrocyte lineage include the regulation of feedback loops with the cell-specific transcriptional activator Sox10 [4].
  • In progenitors with low levels of Sox10, Hes5 further decreases the bioavailability of this protein by transcriptional inhibition and direct sequestration of this activator [4].

Biological context of HES5


Anatomical context of HES5

  • The HLH gene HES5 on the other hand was only detected in chondrocytes [7].
  • The transcription factors Math1 and Brn3.1 are required for hair cell differentiation, and supporting cells express negative regulators of neurogenesis, Hes1 and Hes5 [8].
  • Specific GFP expression in transgenic cell lines was confirmed during neural differentiation marking neural stem cells, neuronal precursors, and glial progeny by Hes5, Dll1, and GFAP, respectively [9].

Regulatory relationships of HES5

  • Here, we report that both Hes1 and Hes5 are directly regulated by Notch activity during retinal development [10].

Other interactions of HES5

  • In the U-bottomed wells, Hes1 and Hes5, which are target genes of the Notch signal, were expressed at higher levels than in the control, flat-bottomed wells [11].


  1. Identification and characterization of human HES2, HES3, and HES5 genes in silico. Katoh, M., Katoh, M. Int. J. Oncol. (2004) [Pubmed]
  2. Structure and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-5. Identification of the neural precursor cell-specific promoter element. Takebayashi, K., Akazawa, C., Nakanishi, S., Kageyama, R. J. Biol. Chem. (1995) [Pubmed]
  3. The Transcription Factor NFIA Controls the Onset of Gliogenesis in the Developing Spinal Cord. Deneen, B., Ho, R., Lukaszewicz, A., Hochstim, C.J., Gronostajski, R.M., Anderson, D.J. Neuron (2006) [Pubmed]
  4. A molecular insight of Hes5-dependent inhibition of myelin gene expression: old partners and new players. Liu, A., Li, J., Marin-Husstege, M., Kageyama, R., Fan, Y., Gelinas, C., Casaccia-Bonnefil, P. EMBO J. (2006) [Pubmed]
  5. Molecular mechanisms for morphogenesis of the central nervous system in mammals. Ishibashi, M. Anatomical science international / Japanese Association of Anatomists. (2004) [Pubmed]
  6. Overexpression of SOCS3 inhibits astrogliogenesis and promotes maintenance of neural stem cells. Cao, F., Hata, R., Zhu, P., Ma, Y.J., Tanaka, J., Hanakawa, Y., Hashimoto, K., Niinobe, M., Yoshikawa, K., Sakanaka, M. J. Neurochem. (2006) [Pubmed]
  7. Differentiation of human mesenchymal stem cells and articular chondrocytes: Analysis of chondrogenic potential and expression pattern of differentiation-related transcription factors. Karlsson, C., Brantsing, C., Svensson, T., Brisby, H., Asp, J., Tallheden, T., Lindahl, A. J. Orthop. Res. (2007) [Pubmed]
  8. Sensory organ development in the inner ear: molecular and cellular mechanisms. Bryant, J., Goodyear, R.J., Richardson, G.P. Br. Med. Bull. (2002) [Pubmed]
  9. Production of Green Fluorescent Protein Transgenic Embryonic Stem Cells Using the GENSAT Bacterial Artificial Chromosome Library. Tomishima, M.J., Hadjantonakis, A.K., Gong, S., Studer, L. Stem Cells (2007) [Pubmed]
  10. Notch activity is downregulated just prior to retinal ganglion cell differentiation. Nelson, B.R., Gumuscu, B., Hartman, B.H., Reh, T.A. Dev. Neurosci. (2006) [Pubmed]
  11. Effect of neurosphere size on the growth rate of human neural stem/progenitor cells. Mori, H., Ninomiya, K., Kino-Oka, M., Shofuda, T., Islam, M.O., Yamasaki, M., Okano, H., Taya, M., Kanemura, Y. J. Neurosci. Res. (2006) [Pubmed]
WikiGenes - Universities