The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

MTA1  -  metastasis associated 1

Homo sapiens

Synonyms: Metastasis-associated protein MTA1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of MTA1


High impact information on MTA1

  • The complex contains the histone deacetylases HDAC1/2, histone-binding proteins, the dermatomyositis-specific autoantigen Mi2beta, a polypeptide related to the metastasis-associated protein 1, and a novel polypeptide of 32 kDa [4].
  • Upregulation of metastatic tumour antigen 1 (MTA1) is associated with the invasiveness and metastatic potential of several human cancers and acts as a co-repressor of nuclear ER-alpha [5].
  • One subunit of NURD was identified as MTA1, a metastasis-associated protein with a region similar to the nuclear receptor core-pressor, N-CoR; and antibodies against NURD partially relieve transcriptional repression by thyroid hormone receptor [6].
  • Activated human lymphocytes and aggressive non-Hodgkin's lymphomas express a homologue of the rat metastasis-associated variant of CD44 [7].
  • MTA1 is also a potent corepressor of ERE transcription, as it blocks the ability of oestradiol to stimulate ER-mediated transcription [1].

Chemical compound and disease context of MTA1


Biological context of MTA1


Anatomical context of MTA1

  • Cancers overexpressing MTA1 protein invaded deeper into the esophageal wall (p < 0.005) and showed significantly higher degrees of lymph node metastasis (p < 0.01), higher pathological stage, more lymphatic involvement and poorer prognosis (p < 0.05) than the remaining cases [15].
  • The intensities of immunostaining of MTA1 protein and acetylated histone H4 in carcinoma tissues (Ca) were compared to normal epithelium (N) contained in the same section [15].
  • MTA1 was overexpressed in HCC cells versus nonmalignant hepatocytes in 31 of 45 HCC specimens (69%) [16].
  • The results suggest that the MTA1 protein may serve multiple functions in cellular signaling, chromosome remodeling and transcription processes that are important in the progression, invasion and growth of metastatic epithelial cells [8].
  • MAGE-D2 and MTA1 message were significantly elevated (> 10-fold, P < 0.01) in the malignant and goblet cell adenocarcinoid tumors but not in the appendicitis-associated carcinoids or normal mucosa [17].

Associations of MTA1 with chemical compounds


Physical interactions of MTA1


Regulatory relationships of MTA1


Other interactions of MTA1

  • Here we report the identification of metastatic-associated protein 1 (MTA1), a component of histone deacetylase (HDAC) and nucleosome-remodelling complexes, as a gene product induced by heregulin-beta1 (HRG) [1].
  • We suggest that MTA1 associates with a different set of transcription factors from MTA2 and that this property may contribute to the metastatic potential of cells overexpressing MTA1 [13].
  • We also report the finding of human MTA3, which is highly homologous to both MTA1 and MTA2 [13].
  • Using a yeast two-hybrid screen with the MTA1 C-terminal domain as bait, we identified MAT1 (ménage á trois 1) as an MTA1-binding protein [9].
  • Here, we explored the possibility of cross-talk between MTA1 and hypoxia-inducible factor-1alpha (HIF-1alpha), a key regulator of angiogenic factors [2].

Analytical, diagnostic and therapeutic context of MTA1


  1. Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor. Mazumdar, A., Wang, R.A., Mishra, S.K., Adam, L., Bagheri-Yarmand, R., Mandal, M., Vadlamudi, R.K., Kumar, R. Nat. Cell Biol. (2001) [Pubmed]
  2. Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1. Yoo, Y.G., Kong, G., Lee, M.O. EMBO J. (2006) [Pubmed]
  3. Metastasis-associated protein (MTA)1 enhances migration, invasion, and anchorage-independent survival of immortalized human keratinocytes. Mahoney, M.G., Simpson, A., Jost, M., Noé, M., Kari, C., Pepe, D., Choi, Y.W., Uitto, J., Rodeck, U. Oncogene (2002) [Pubmed]
  4. The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities. Zhang, Y., LeRoy, G., Seelig, H.P., Lane, W.S., Reinberg, D. Cell (1998) [Pubmed]
  5. A naturally occurring MTA1 variant sequesters oestrogen receptor-alpha in the cytoplasm. Kumar, R., Wang, R.A., Mazumdar, A., Talukder, A.H., Mandal, M., Yang, Z., Bagheri-Yarmand, R., Sahin, A., Hortobagyi, G., Adam, L., Barnes, C.J., Vadlamudi, R.K. Nature (2002) [Pubmed]
  6. NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. Xue, Y., Wong, J., Moreno, G.T., Young, M.K., Côté, J., Wang, W. Mol. Cell (1998) [Pubmed]
  7. Activated human lymphocytes and aggressive non-Hodgkin's lymphomas express a homologue of the rat metastasis-associated variant of CD44. Koopman, G., Heider, K.H., Horst, E., Adolf, G.R., van den Berg, F., Ponta, H., Herrlich, P., Pals, S.T. J. Exp. Med. (1993) [Pubmed]
  8. Tumor metastasis-associated human MTA1 gene and its MTA1 protein product: role in epithelial cancer cell invasion, proliferation and nuclear regulation. Nicolson, G.L., Nawa, A., Toh, Y., Taniguchi, S., Nishimori, K., Moustafa, A. Clin. Exp. Metastasis (2003) [Pubmed]
  9. MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions. Talukder, A.H., Mishra, S.K., Mandal, M., Balasenthil, S., Mehta, S., Sahin, A.A., Barnes, C.J., Kumar, R. J. Biol. Chem. (2003) [Pubmed]
  10. Breast tumors that overexpress nuclear metastasis-associated 1 (MTA1) protein have high recurrence risks but enhanced responses to systemic therapies. Martin, M.D., Hilsenbeck, S.G., Mohsin, S.K., Hopp, T.A., Clark, G.M., Osborne, C.K., Allred, D.C., O'connell, P. Breast Cancer Res. Treat. (2006) [Pubmed]
  11. MTA1 overexpression correlates significantly with tumor grade and angiogenesis in human breast cancers. Jang, K.S., Paik, S.S., Chung, H., Oh, Y.H., Kong, G. Cancer Sci. (2006) [Pubmed]
  12. Bcl-2 overexpression and hypoxia synergistically act to modulate vascular endothelial growth factor expression and in vivo angiogenesis in a breast carcinoma line. Biroccio, A., Candiloro, A., Mottolese, M., Sapora, O., Albini, A., Zupi, G., Del Bufalo, D. FASEB J. (2000) [Pubmed]
  13. The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity. Yao, Y.L., Yang, W.M. J. Biol. Chem. (2003) [Pubmed]
  14. Emerging roles of MTA family members in human cancers. Kumar, R., Wang, R.A., Bagheri-Yarmand, R. Semin. Oncol. (2003) [Pubmed]
  15. Expression of the metastasis-associated MTA1 protein and its relationship to deacetylation of the histone H4 in esophageal squamous cell carcinomas. Toh, Y., Ohga, T., Endo, K., Adachi, E., Kusumoto, H., Haraguchi, M., Okamura, T., Nicolson, G.L. Int. J. Cancer (2004) [Pubmed]
  16. Overexpression of metastatic tumor antigen 1 in hepatocellular carcinoma: Relationship to vascular invasion and estrogen receptor-alpha. Moon, W.S., Chang, K., Tarnawski, A.S. Hum. Pathol. (2004) [Pubmed]
  17. Genetic differentiation of appendiceal tumor malignancy: a guide for the perplexed. Modlin, I.M., Kidd, M., Latich, I., Zikusoka, M.N., Eick, G.N., Mane, S.M., Camp, R.L. Ann. Surg. (2006) [Pubmed]
  18. MTA1, a transcriptional activator of breast cancer amplified sequence 3. Gururaj, A.E., Singh, R.R., Rayala, S.K., Holm, C., den Hollander, P., Zhang, H., Balasenthil, S., Talukder, A.H., Landberg, G., Kumar, R. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  19. Metastasis-associated protein 1 deregulation causes inappropriate mammary gland development and tumorigenesis. Bagheri-Yarmand, R., Talukder, A.H., Wang, R.A., Vadlamudi, R.K., Kumar, R. Development (2004) [Pubmed]
  20. Metastasis-associated protein 1 enhances angiogenesis by stabilization of HIF-1alpha. Moon, H.E., Cheon, H., Chun, K.H., Lee, S.K., Kim, Y.S., Jung, B.K., Park, J.A., Kim, S.H., Jeong, J.W., Lee, M.S. Oncol. Rep. (2006) [Pubmed]
  21. Novel mechanisms of resistance to endocrine therapy: genomic and nongenomic considerations. Gururaj, A.E., Rayala, S.K., Vadlamudi, R.K., Kumar, R. Clin. Cancer Res. (2006) [Pubmed]
  22. Metastasis-associated protein 1 (MTA1) is an essential downstream effector of the c-MYC oncoprotein. Zhang, X.Y., DeSalle, L.M., Patel, J.H., Capobianco, A.J., Yu, D., Thomas-Tikhonenko, A., McMahon, S.B. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  23. Metastasis-associated protein 1 interacts with NRIF3, an estrogen-inducible nuclear receptor coregulator. Talukder, A.H., Gururaj, A., Mishra, S.K., Vadlamudi, R.K., Kumar, R. Mol. Cell. Biol. (2004) [Pubmed]
  24. Expression of metastasis-associated protein 1 (MTA1) in benign endometrium and endometrial adenocarcinomas. Balasenthil, S., Broaddus, R.R., Kumar, R. Hum. Pathol. (2006) [Pubmed]
  25. Inhibitory effects of a luteinizing hormone-releasing hormone agonist on basal and epidermal growth factor-induced cell proliferation and metastasis-associated properties in human epidermoid carcinoma A431 cells. Huang, Y.T., Hwang, J.J., Lee, L.T., Liebow, C., Lee, P.P., Ke, F.C., Lo, T.B., Schally, A.V., Lee, M.T. Int. J. Cancer (2002) [Pubmed]
  26. The role of metastasis-associated protein 1 in prostate cancer progression. Hofer, M.D., Kuefer, R., Varambally, S., Li, H., Ma, J., Shapiro, G.I., Gschwend, J.E., Hautmann, R.E., Sanda, M.G., Giehl, K., Menke, A., Chinnaiyan, A.M., Rubin, M.A. Cancer Res. (2004) [Pubmed]
WikiGenes - Universities