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Gene Review

MSTO1  -  misato 1, mitochondrial distribution and...

Homo sapiens

Synonyms: FLJ10504, LST005, MST, Protein misato homolog 1, SLTP005, ...
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Disease relevance of MSTO1

  • In this paper we evaluate the cytokine expression patterns of T-cells and the plasmatic levels of nitrite and nitrate in patients with localized cutaneous leishmaniasis (LCL) as well as endemic non-infected individuals with positive (MST) and negative (NI) Montenegro skin test, without previous history of leishmanial lesions [1].

High impact information on MSTO1

  • Cell viability declined markedly in the AS-negative cell lines 2591 and MSTO but not in the AS-positive cell line, 28 [2].
  • Three out of four cell lines showed a different level of c-erbB-2 expression, the highest being detected on the MSTO 211 H cell line (fibroblastic phenotype), whereas MMGe-1 resulted negative [3].
  • However, the low frequency of IL-4+ T-cells, high IFN-gamma+/IL-10+ cell ratio as well as elevated nitrite and nitrate plasma levels observed in MST, suggested that despite basal levels of cytokines, a high proportion of Type-1 over Type-2 cytokines would count to prevent parasite growth and lesion development [1].

Analytical, diagnostic and therapeutic context of MSTO1

  • In addition, we found evidence of a metric relation between rotational flow relative to the head and fMRI signals in a subregion of MST [4].


  1. Mixed cytokine profile during active cutaneous leishmaniasis and in natural resistance. Baratta-Masini, A., Teixeira-Carvalho, A., Malaquias, L.C., Mayrink, W., Martins-Filho, O.A., Corr??a-Oliveira, R. Front. Biosci. (2007) [Pubmed]
  2. In vivo Loss of Expression of Argininosuccinate Synthetase in Malignant Pleural Mesothelioma Is a Biomarker for Susceptibility to Arginine Depletion. Szlosarek, P.W., Klabatsa, A., Pallaska, A., Sheaff, M., Smith, P., Crook, T., Grimshaw, M.J., Steele, J.P., Rudd, R.M., Balkwill, F.R., Fennell, D.A. Clin. Cancer Res. (2006) [Pubmed]
  3. Synergistic effect of the anti-HER-2/neu antibody and cisplatin in immortalized and primary mesothelioma cell lines. Toma, S., Colucci, L., Scarabelli, L., Scaramuccia, A., Emionite, L., Betta, P.G., Mutti, L. J. Cell. Physiol. (2002) [Pubmed]
  4. Representation of head-centric flow in the human motion complex. Goossens, J., Dukelow, S.P., Menon, R.S., Vilis, T., van den Berg, A.V. J. Neurosci. (2006) [Pubmed]
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