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Gene Review

STEAP3  -  STEAP family member 3, metalloreductase

Homo sapiens

Synonyms: AHMIO2, Dudulin-2, Metalloreductase STEAP3, STMP3, Six-transmembrane epithelial antigen of prostate 3, ...
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High impact information on STEAP3

  • Moreover, TSAP6 enhanced the susceptibility of cells to apoptosis and cooperated with Nix to exacerbate this effect [1].
  • Furthermore, TSAP6 small interfering RNA inhibited apoptosis in TSAP6-overexpressing cells [1].
  • Cell-cycle studies indicated that TSAP6 could augment Myt1 activity [1].
  • Analysis of the TSAP6 promoter identified a functional p53-responsive element [1].
  • We have previously described a transcript designated tumor suppressor activated pathway-6 (TSAP6) that is up-regulated in the p53-inducible cell line, LTR6 [1].

Biological context of STEAP3


Other interactions of STEAP3

  • Functional studies demonstrated that TSAP6 antisense cDNA diminished levels of the 50- to 55-kDa protein and decreased significantly the levels of p53-induced apoptosis [1].


  1. The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase. Passer, B.J., Nancy-Portebois, V., Amzallag, N., Prieur, S., Cans, C., Roborel de Climens, A., Fiucci, G., Bouvard, V., Tuynder, M., Susini, L., Morchoisne, S., Crible, V., Lespagnol, A., Dausset, J., Oren, M., Amson, R., Telerman, A. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. The Steap proteins are metalloreductases. Ohgami, R.S., Campagna, D.R., McDonald, A., Fleming, M.D. Blood (2006) [Pubmed]
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