The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

BNIP3L  -  BCL2/adenovirus E1B 19kDa interacting...

Homo sapiens

Synonyms: Adenovirus E1B19K-binding protein B5, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like, BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A, BNIP3A, BNIP3H, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of BNIP3L


High impact information on BNIP3L

  • Moreover, TSAP6 enhanced the susceptibility of cells to apoptosis and cooperated with Nix to exacerbate this effect [4].
  • This study demonstrates a direct link between HIF-1alpha and a proapoptotic member of the Bcl-2 family and offers a reasonable physiological function for members of the Bcl-2 subfamily, including Nip3 and its close relative Nix [5].
  • Polymerase chain reaction (PCR)-based transcriptional patterning confirmed the increased expression of Nix during human erythropoiesis with a pattern similar to that of Bcl-xL and glycophorin A and opposite that of Bcl-2 [6].
  • The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation [6].
  • Our in silico screening strategy indicated that a hypoxia-inducible proapoptotic member of the Bcl-2 gene family called Nix is expressed during erythropoiesis [6].

Chemical compound and disease context of BNIP3L


Biological context of BNIP3L


Anatomical context of BNIP3L


Associations of BNIP3L with chemical compounds

  • Nix, a pro-apoptotic BH3-only protein, promotes apoptosis of non-neuronal cells, although the mechanisms involved remain incompletely understood [7].
  • These can serve to organize cofactor interactions with biomolecules, as was recently demonstrated for a biotin-selective RNA aptamer that depends on a direct biotin-magnesium interaction for recognition of biotin (Nix, J.; Sussman, D.; Wilson, C. J. Mol. Biol. 2000, 296, 1235-1244) [14].
  • An observational, epidemiological study was undertaken to evaluate the safety of permethrin 1% creme rinse (Nix) for treatment of head lice infestations [15].
  • OBJECTIVE: To compare the pediculicidal activity of Ovide lotion and its active ingredient, 0.5% malathion, with Nix and its active ingredient, 1% permethrin, in permethrin-resistant head lice [16].
  • We treated 53 men with the diagnosis of PP with either 1% lindane (Kwell) shampoo for four minutes or 1% permethrin (Nix) creme rinse for ten minutes, according to random assignment [17].

Other interactions of BNIP3L


Analytical, diagnostic and therapeutic context of BNIP3L

  • The placental expression of BNip3/Nix has been investigated with immunohistochemistry by the use of specific human BNip3/Nix antibodies [18].
  • Co-immunoprecipitation and in vitro binding studies confirmed a direct interaction between POSH and Nix in mammalian cells [7].
  • Computational sequence analysis techniques, BLAST and NIX, were used to assemble a physical map of MRIII, consisting of three overlapping bacterial artificial chromosome (BAC) clones, 297N7, 963H4 and 795F17, from the RPCI-11 library [19].
  • The percentage length of the file visible was significantly less for Sens-A-Ray (P=0.02) and for Nix NF45-100 film (P<0.005) when compared with D-speed film processed with conventional chemistry [20].


  1. Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3. Kanzawa, T., Zhang, L., Xiao, L., Germano, I.M., Kondo, Y., Kondo, S. Oncogene (2005) [Pubmed]
  2. HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Sowter, H.M., Ratcliffe, P.J., Watson, P., Greenberg, A.H., Harris, A.L. Cancer Res. (2001) [Pubmed]
  3. Analysis of the candidate 8p21 tumour suppressor, BNIP3L, in breast and ovarian cancer. Lai, J., Flanagan, J., Phillips, W.A., Chenevix-Trench, G., Arnold, J. Br. J. Cancer (2003) [Pubmed]
  4. The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase. Passer, B.J., Nancy-Portebois, V., Amzallag, N., Prieur, S., Cans, C., Roborel de Climens, A., Fiucci, G., Bouvard, V., Tuynder, M., Susini, L., Morchoisne, S., Crible, V., Lespagnol, A., Dausset, J., Oren, M., Amson, R., Telerman, A. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  5. Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Bruick, R.K. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  6. The proapoptotic factor Nix is coexpressed with Bcl-xL during terminal erythroid differentiation. Aerbajinai, W., Giattina, M., Lee, Y.T., Raffeld, M., Miller, J.L. Blood (2003) [Pubmed]
  7. Proapoptotic Nix Activates the JNK Pathway by Interacting with POSH and Mediates Death in a Parkinson Disease Model. Wilhelm, M., Xu, Z., Kukekov, N.V., Gire, S., Greene, L.A. J. Biol. Chem. (2007) [Pubmed]
  8. Eradication of head lice with a single treatment. DiNapoli, J.B., Austin, R.D., Englender, S.J., Gomez, M.P., Barrett, J.F. American journal of public health. (1988) [Pubmed]
  9. Isolation, mapping, and functional analysis of a novel human cDNA (BNIP3L) encoding a protein homologous to human NIP3. Matsushima, M., Fujiwara, T., Takahashi, E., Minaguchi, T., Eguchi, Y., Tsujimoto, Y., Suzumori, K., Nakamura, Y. Genes Chromosomes Cancer (1998) [Pubmed]
  10. EGR2 induces apoptosis in various cancer cell lines by direct transactivation of BNIP3L and BAK. Unoki, M., Nakamura, Y. Oncogene (2003) [Pubmed]
  11. Selective silencing of the hypoxia-inducible factor 1 target gene BNIP3 by histone deacetylation and methylation in colorectal cancer. Bacon, A.L., Fox, S., Turley, H., Harris, A.L. Oncogene (2007) [Pubmed]
  12. Increased expression of 19-kD interacting protein-3-like protein and the relationship to apoptosis in the lung of rats with severe acute pancreatitis. Nakamura, H., Honda, H., Tashiro, M., Taguchi, M., Yoshikawa, H., Otsuki, M. Crit. Care Med. (2003) [Pubmed]
  13. An intranuclear pathogen [nuclear inclusion X (NIX)] associated with massive mortalities of the Pacific razor clam, Siliqua patula. Elston, R.A. J. Invertebr. Pathol. (1986) [Pubmed]
  14. Interaction of biotin with Mg-O bonds: bifunctional binding and recognition of biotin and related ligands by the Mg(15-crown-5)2+ unit. Sanchez, E.R., Gessel, M.C., Groy, T.L., Caudle, M.T. J. Am. Chem. Soc. (2002) [Pubmed]
  15. Postmarketing surveillance study of permethrin creme rinse. Andrews, E.B., Joseph, M.C., Magenheim, M.J., Tilson, H.H., Doi, P.A., Schultz, M.W. American journal of public health. (1992) [Pubmed]
  16. Permethrin-resistant human head lice, Pediculus capitis, and their treatment. Yoon, K.S., Gao, J.R., Lee, S.H., Clark, J.M., Brown, L., Taplin, D. Archives of dermatology. (2003) [Pubmed]
  17. Treatment of pediculosis pubis. Clinical comparison of efficacy and tolerance of 1% lindane shampoo vs 1% permethrin creme rinse. Kalter, D.C., Sperber, J., Rosen, T., Matarasso, S. Archives of dermatology. (1987) [Pubmed]
  18. Placental localization and expression of the cell death factors BNip3 and Nix in preeclampsia, intrauterine growth retardation and HELLP syndrome. Stepan, H., Leo, C., Purz, S., Höckel, M., Horn, L.C. Eur. J. Obstet. Gynecol. Reprod. Biol. (2005) [Pubmed]
  19. Physical and transcript map of the minimally deleted region III on 17p implicated in the early development of Barrett's oesophageal adenocarcinoma. Dunn, J.R., Risk, J.M., Langan, J.E., Marlee, D., Ellis, A., Campbell, F., Watson, A.J., Field, J.K. Oncogene (2003) [Pubmed]
  20. An in vitro comparison of 10 radiographic methods for working length estimation. Rushton, V.E., Shearer, A.C., Horner, K., Czajka, J. International endodontic journal. (1995) [Pubmed]
WikiGenes - Universities