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MeSH Review

Myocardial Ischemia

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Disease relevance of Myocardial Ischemia


Psychiatry related information on Myocardial Ischemia


High impact information on Myocardial Ischemia


Chemical compound and disease context of Myocardial Ischemia


Biological context of Myocardial Ischemia


Anatomical context of Myocardial Ischemia


Gene context of Myocardial Ischemia

  • METHODS AND RESULTS: Myocardial tissue from 27 patients with end-stage heart failure (various etiologies: ischemic heart disease, n=16; idiopathic dilated cardiomyopathy, n=10; and valvular heart disease, n=1), 2 septic patients, and 8 normal control subjects was immunostained with antisera to COX-2 and NF-kappaB [30].
  • These observations not only suggest a potential therapeutic role for recombinant human EPO in the treatment of myocardial ischemia and infarction by preventing apoptosis and attenuating postinfarct deterioration in hemodynamic function, but also predict that EPO is likely a tissue-protective cytokine in other organs as well [31].
  • CONCLUSIONS: This study is the first to show that myocardial ischemia and reperfusion induced HGF expression in various organs in vivo [32].
  • VEGF-C and its receptors thus constitute an apparently redundant pathway for postnatal angiogenesis and may represent an alternative to VEGF-A for strategies of therapeutic angiogenesis in patients with limb and/or myocardial ischemia [33].
  • Endothelin-1 (ET-1) is an autocrine factor in the mammalian heart important in enhancing cardiac performance, protecting against myocardial ischemia, and initiating the development of cardiac hypertrophy [34].

Analytical, diagnostic and therapeutic context of Myocardial Ischemia


  1. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators. Pfeffer, M.A., Braunwald, E., Moyé, L.A., Basta, L., Brown, E.J., Cuddy, T.E., Davis, B.R., Geltman, E.M., Goldman, S., Flaker, G.C. N. Engl. J. Med. (1992) [Pubmed]
  2. A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase. Melov, S., Schneider, J.A., Day, B.J., Hinerfeld, D., Coskun, P., Mirra, S.S., Crapo, J.D., Wallace, D.C. Nat. Genet. (1998) [Pubmed]
  3. Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart. Giordano, F.J., Ping, P., McKirnan, M.D., Nozaki, S., DeMaria, A.N., Dillmann, W.H., Mathieu-Costello, O., Hammond, H.K. Nat. Med. (1996) [Pubmed]
  4. Caffeine and cardiac arrhythmias. Myers, M.G. Ann. Intern. Med. (1991) [Pubmed]
  5. Nifedipine in myocardial ischemia, systemic hypertension, and other cardiovascular disorders. Ferlinz, J. Ann. Intern. Med. (1986) [Pubmed]
  6. How much of the increased incidence of heart failure in rheumatoid arthritis is attributable to traditional cardiovascular risk factors and ischemic heart disease? Crowson, C.S., Nicola, P.J., Kremers, H.M., O'Fallon, W.M., Therneau, T.M., Jacobsen, S.J., Roger, V.L., Ballman, K.V., Gabriel, S.E. Arthritis Rheum. (2005) [Pubmed]
  7. Nicotine patch therapy in smoking cessation reduces the extent of exercise-induced myocardial ischemia. Mahmarian, J.J., Moyé, L.A., Nasser, G.A., Nagueh, S.F., Bloom, M.F., Benowitz, N.L., Verani, M.S., Byrd, W.G., Pratt, C.M. J. Am. Coll. Cardiol. (1997) [Pubmed]
  8. Effects of sildenafil on myocardial infarct size, microvascular function, and acute ischemic left ventricular dilation. Reffelmann, T., Kloner, R.A. Cardiovasc. Res. (2003) [Pubmed]
  9. Protection against ischemic heart disease in the Belgian Physical Fitness Study: physical fitness rather than physical activity? Sobolski, J., Kornitzer, M., De Backer, G., Dramaix, M., Abramowicz, M., Degre, S., Denolin, H. Am. J. Epidemiol. (1987) [Pubmed]
  10. Patients with Alzheimer's disease may be particularly susceptible to adverse effects of statins. Algotsson, A., Winblad, B. Dementia and geriatric cognitive disorders. (2004) [Pubmed]
  11. Association of mutations in the apolipoprotein B gene with hypercholesterolemia and the risk of ischemic heart disease. Tybjaerg-Hansen, A., Steffensen, R., Meinertz, H., Schnohr, P., Nordestgaard, B.G. N. Engl. J. Med. (1998) [Pubmed]
  12. Cocaine-associated myocardial ischemia. Derlet, R.W., Horowitz, B.Z. N. Engl. J. Med. (1996) [Pubmed]
  13. Effect of amlodipine on morbidity and mortality in severe chronic heart failure. Prospective Randomized Amlodipine Survival Evaluation Study Group. Packer, M., O'Connor, C.M., Ghali, J.K., Pressler, M.L., Carson, P.E., Belkin, R.N., Miller, A.B., Neuberg, G.W., Frid, D., Wertheimer, J.H., Cropp, A.B., DeMets, D.L. N. Engl. J. Med. (1996) [Pubmed]
  14. The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion. Anderson, T.J., Meredith, I.T., Yeung, A.C., Frei, B., Selwyn, A.P., Ganz, P. N. Engl. J. Med. (1995) [Pubmed]
  15. A prospective evaluation of an angiotensin-converting-enzyme gene polymorphism and the risk of ischemic heart disease. Lindpaintner, K., Pfeffer, M.A., Kreutz, R., Stampfer, M.J., Grodstein, F., LaMotte, F., Buring, J., Hennekens, C.H. N. Engl. J. Med. (1995) [Pubmed]
  16. Reduction in myocardial ischemia with nitroglycerin or nitroglycerin plus phenylephrine administered during acute myocardial infarction. Borer, J.S., Redwood, D.R., Levitt, B., Cagin, N., Bianchi, C., Vallin, H., Epstein, S.E. N. Engl. J. Med. (1975) [Pubmed]
  17. Angina due to coronary microvascular disease in hypertensive patients without left ventricular hypertrophy. Brush, J.E., Cannon, R.O., Schenke, W.H., Bonow, R.O., Leon, M.B., Maron, B.J., Epstein, S.E. N. Engl. J. Med. (1988) [Pubmed]
  18. Nifedipine therapy for coronary-artery spasm. Experience in 127 patients. Antman, E., Muller, J., Goldberg, S., MacAlpin, R., Rubenfire, M., Tabatznik, B., Liang, C.S., Heupler, F., Achuff, S., Reichek, N., Geltman, E., Kerin, N.Z., Neff, R.K., Braunwald, E. N. Engl. J. Med. (1980) [Pubmed]
  19. Serotonin and acute ischemic heart disease. Hillis, L.D., Lange, R.A. N. Engl. J. Med. (1991) [Pubmed]
  20. Short-term effects of carbon monoxide exposure on the exercise performance of subjects with coronary artery disease. Allred, E.N., Bleecker, E.R., Chaitman, B.R., Dahms, T.E., Gottlieb, S.O., Hackney, J.D., Pagano, M., Selvester, R.H., Walden, S.M., Warren, J. N. Engl. J. Med. (1989) [Pubmed]
  21. Why is diabetes mellitus a stronger risk factor for fatal ischemic heart disease in women than in men? The Rancho Bernardo Study. Barrett-Connor, E.L., Cohn, B.A., Wingard, D.L., Edelstein, S.L. JAMA (1991) [Pubmed]
  22. Beta-adrenergic stimulation with isoproterenol enhances left ventricular diastolic performance in hypertrophic cardiomyopathy despite potentiation of myocardial ischemia. Comparison to rapid atrial pacing. Udelson, J.E., Cannon, R.O., Bacharach, S.L., Rumble, T.F., Bonow, R.O. Circulation (1989) [Pubmed]
  23. Intravenous nitroglycerin in acute myocardial infarction. Flaherty, J.T., Reid, P.R., Kelly, D.T., Taylor, D.R., Weisfeldt, M.L., Pitt, B. Circulation (1975) [Pubmed]
  24. Coronary vasoconstriction induced by vasopressin. Production of myocardial ischemia in dogs by constriction of nondiseased small vessels. Maturi, M.F., Martin, S.E., Markle, D., Maxwell, M., Burruss, C.R., Speir, E., Greene, R., Ro, Y.M., Vitale, D., Green, M.V. Circulation (1991) [Pubmed]
  25. Serotonin selectively aggravates subendocardial ischemia distal to a coronary artery stenosis during exercise. Bache, R.J., Stark, R.P., Duncker, D.J. Circulation (1992) [Pubmed]
  26. The influence of hypertonic mannitol on regional myocardial blood flow during acute and chronic myocardial ischemia in anesthetized and awake intact dogs. Willerson, J.T., Watson, J.T., Hutton, I., Fixler, D.E., Curry, G.C., Templeton, G.H. J. Clin. Invest. (1975) [Pubmed]
  27. Reduction of experimental canine myocardial reperfusion injury by a monoclonal antibody (anti-Mo1, anti-CD11b) that inhibits leukocyte adhesion. Simpson, P.J., Todd, R.F., Fantone, J.C., Mickelson, J.K., Griffin, J.D., Lucchesi, B.R. J. Clin. Invest. (1988) [Pubmed]
  28. Priming of polymorphonuclear neutrophils by atrial natriuretic peptide in vitro. Wiedermann, C.J., Niedermühlbichler, M., Braunsteiner, H., Widermann, C.J. J. Clin. Invest. (1992) [Pubmed]
  29. Regional myocardial downregulation of the inhibitory guanosine triphosphate-binding protein (Gi alpha 2) and beta-adrenergic receptors in a porcine model of chronic episodic myocardial ischemia. Hammond, H.K., Roth, D.A., McKirnan, M.D., Ping, P. J. Clin. Invest. (1993) [Pubmed]
  30. Induction of cyclooxygenase-2 and activation of nuclear factor-kappaB in myocardium of patients with congestive heart failure. Wong, S.C., Fukuchi, M., Melnyk, P., Rodger, I., Giaid, A. Circulation (1998) [Pubmed]
  31. Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling. Calvillo, L., Latini, R., Kajstura, J., Leri, A., Anversa, P., Ghezzi, P., Salio, M., Cerami, A., Brines, M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  32. Enhanced expression of hepatocyte growth factor/c-Met by myocardial ischemia and reperfusion in a rat model. Ono, K., Matsumori, A., Shioi, T., Furukawa, Y., Sasayama, S. Circulation (1997) [Pubmed]
  33. Vascular endothelial growth factor-C (VEGF-C/VEGF-2) promotes angiogenesis in the setting of tissue ischemia. Witzenbichler, B., Asahara, T., Murohara, T., Silver, M., Spyridopoulos, I., Magner, M., Principe, N., Kearney, M., Hu, J.S., Isner, J.M. Am. J. Pathol. (1998) [Pubmed]
  34. Localization of functional endothelin receptor signaling complexes in cardiac transverse tubules. Robu, V.G., Pfeiffer, E.S., Robia, S.L., Balijepalli, R.C., Pi, Y., Kamp, T.J., Walker, J.W. J. Biol. Chem. (2003) [Pubmed]
  35. Regulation of intercellular adhesion molecule-1 (ICAM-1) in ischemic and reperfused canine myocardium. Kukielka, G.L., Hawkins, H.K., Michael, L., Manning, A.M., Youker, K., Lane, C., Entman, M.L., Smith, C.W., Anderson, D.C. J. Clin. Invest. (1993) [Pubmed]
  36. Myocardial ischemia during cocaine withdrawal. Nademanee, K., Gorelick, D.A., Josephson, M.A., Ryan, M.A., Wilkins, J.N., Robertson, H.A., Mody, F.V., Intarachot, V. Ann. Intern. Med. (1989) [Pubmed]
  37. Silent ischemia as a central problem: regional brain activation compared in silent and painful myocardial ischemia. Rosen, S.D., Paulesu, E., Nihoyannopoulos, P., Tousoulis, D., Frackowiak, R.S., Frith, C.D., Jones, T., Camici, P.G. Ann. Intern. Med. (1996) [Pubmed]
  38. Impaired endothelium-dependent vasodilation of coronary resistance vessels is associated with exercise-induced myocardial ischemia. Zeiher, A.M., Krause, T., Schächinger, V., Minners, J., Moser, E. Circulation (1995) [Pubmed]
  39. Increased carotid artery intimal-medial thickness in asymptomatic older subjects with exercise-induced myocardial ischemia. Nagai, Y., Metter, E.J., Earley, C.J., Kemper, M.K., Becker, L.C., Lakatta, E.G., Fleg, J.L. Circulation (1998) [Pubmed]
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