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Gene Review:

PPP6R3 - protein phosphatase 6, regulatory subunit 3

Homo sapiens

Synonyms: C11orf23, DKFZp781E17107, DKFZp781E2374, DKFZp781O2362, FLJ11058, ...

Stefansson, B. et al., Soares, M. et al., Twells, R.C. et al., Timsit, J.F. et al., Metnitz, P.G. et al., et al.

Capuzzo, Moreno, Jordan, Bauer, Alvisi, Metnitz, Twells, Metzker, Brown, Cox, Garey, Hammond, Hey, Levy, Nakagawa, Philips, Todd, Hess, Metnitz, Moreno, Almeida, Jordan, Bauer, Campos, Iapichino, Edbrooke, Capuzzo, Le Gall, Soares, Salluh, Timsit, Fosse, Troché, De Lassence, Alberti, Garrouste-Orgeas, Azoulay, Chevret, Moine, Cohen,

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Disease relevance of SAPS3

CONCLUSIONS: The SAPS 3 admission prognostic model at ICU admission, in particular its customized equation for CSA, was accurate in our cohort of critically ill patients with cancer [1].

High impact information on SAPS3

C11orf23 has similarity to the SIT4 (sporulation-induced transcript 4)-associated protein (SAP) family of yeast proteins, which are involved in regulation of the cell cycle [2].
CONCLUSIONS: The SAPS 3 study was able to provide a high-quality multinational database, reflecting heterogeneity of current ICU case-mix and typology [3].
MEASUREMENTS AND MAIN RESULTS: The LOD and SAPS II scores were calculated during the first (SAPS1, LOD1), second (SAPS2, LOD2), and third (SAPS3, LOD3) calendar days [4].

Analytical, diagnostic and therapeutic context of SAPS3

Antibodies were generated, distribution of endogenous PP6, PP6R1, PP6R2, and PP6R3 proteins was examined by immunoblotting, and the abundance of mRNA and protein in various tissues did not match [5].
Validation of the SAPS 3 admission prognostic model in patients with cancer in need of intensive care [1].
DESIGN AND SETTING: Prospective international multicentre study in 19 ICUs participating in the HRQOL substudy of the SAPS 3 project [6].

References

Validation of the SAPS 3 admission prognostic model in patients with cancer in need of intensive care. Soares, M., Salluh, J.I. Intensive care medicine. (2006) [Pubmed]
The sequence and gene characterization of a 400-kb candidate region for IDDM4 on chromosome 11q13. Twells, R.C., Metzker, M.L., Brown, S.D., Cox, R., Garey, C., Hammond, H., Hey, P.J., Levy, E., Nakagawa, Y., Philips, M.S., Todd, J.A., Hess, J.F. Genomics (2001) [Pubmed]
SAPS 3--From evaluation of the patient to evaluation of the intensive care unit. Part 1: Objectives, methods and cohort description. Metnitz, P.G., Moreno, R.P., Almeida, E., Jordan, B., Bauer, P., Campos, R.A., Iapichino, G., Edbrooke, D., Capuzzo, M., Le Gall, J.R. Intensive care medicine. (2005) [Pubmed]
Accuracy of a composite score using daily SAPS II and LOD scores for predicting hospital mortality in ICU patients hospitalized for more than 72 h. Timsit, J.F., Fosse, J.P., Troché, G., De Lassence, A., Alberti, C., Garrouste-Orgeas, M., Azoulay, E., Chevret, S., Moine, P., Cohen, Y. Intensive care medicine. (2001) [Pubmed]
Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon. Stefansson, B., Brautigan, D.L. J. Biol. Chem. (2006) [Pubmed]
Predictors of early recovery of health status after intensive care. Capuzzo, M., Moreno, R.P., Jordan, B., Bauer, P., Alvisi, R., Metnitz, P.G. Intensive care medicine. (2006) [Pubmed]

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PPP6R3	Bos taurus
PPP6R3	Canis lupus familiaris
ppp6r3	Danio rerio
PPP6R3	Gallus gallus
SAPS3	Macaca mulatta
Ppp6r3	Mus musculus
PPP6R3	Pan troglodytes
Ppp6r3	Rattus norvegicus
ppp6r3	Xenopus (Silurana) tropicalis

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