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Gene Review

ASIC4  -  acid sensing (proton gated) ion channel...

Homo sapiens

Synonyms: ACCN4, Acid-sensing ion channel 4, Amiloride-sensitive cation channel 4, Amiloride-sensitive cation channel 4, pituitary, BNAC4
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Disease relevance of ACCN4


High impact information on ACCN4

  • ASIC4 cannot be activated by a drop of extracellular pH in Xenopus oocytes, suggesting association with other subunits or activation by a ligand different from protons [3].
  • ASIC4 is 97% identical between rat and human and shows strongest expression in pituitary gland [3].


  1. Acid-sensing ion channel (ASIC) 4 gene: physical mapping, genomic organisation, and evaluation as a candidate for paroxysmal dystonia. Gründer, S., Geisler, H.S., Rainier, S., Fink, J.K. Eur. J. Hum. Genet. (2001) [Pubmed]
  2. Acid-sensing ionic channels in the rat vestibular endorgans and ganglia. Mercado, F., López, I.A., Acuna, D., Vega, R., Soto, E. J. Neurophysiol. (2006) [Pubmed]
  3. A new member of acid-sensing ion channels from pituitary gland. Gründer, S., Geissler, H.S., Bässler, E.L., Ruppersberg, J.P. Neuroreport (2000) [Pubmed]
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