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Gene Review

ASIC3  -  acid sensing (proton gated) ion channel 3

Homo sapiens

Synonyms: ACCN3, Acid-sensing ion channel 3, Amiloride-sensitive cation channel 3, DRASIC, Neuronal amiloride-sensitive cation channel 3, ...
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Disease relevance of ACCN3

  • 4. CIPP mRNA is found at a significant level in the same dorsal root ganglion neuronal cell population that expresses the ASIC3 subunit, i.e. mainly in the small nociceptive neurons [1].
  • Because acidic luminal fluid in the cystic fibrosis airway and lung tends to stimulate ASIC3 channel expression and activity, the interaction of ASIC3 and CFTR may contribute to defective salt and fluid transepithelial transport in the cystic fibrotic pulmonary system [2].
  • The ASIC1b and ASIC3 subunits are specifically expressed in sensory ganglia neurons and are candidate sensors of peripheral acidosis [3].
  • This final property makes ASIC3 a "coincidence detector" of three molecules that appear during ischemia, thereby allowing it to better detect acidosis caused by ischemia than other forms of systemic acidosis such as hypercapnia [4].
  • Sustained currents through ASIC3 ion channels at the modest pH changes that occur during myocardial ischemia [5].

High impact information on ACCN3

  • Acid-sensing ion channel 3 (ASIC3), a proton-gated ion channel of the degenerins/epithelial sodium channel (DEG/ENaC) receptor family is expressed predominantly in sensory neurons including nociceptive neurons responding to protons [6].
  • On the other hand, cAMP-activated CFTR activity was significantly inhibited following constitutive activation of putative ASIC3 at pH 6 [2].
  • ASIC3 and these interacting proteins were expressed in dorsal root ganglia and spinal cord, and PSD-95 co-precipitated ASIC3 from spinal cord [7].
  • The finding that multiple PDZ-containing proteins bind ASIC3 and can influence its presence in the plasma membrane suggests that they may play an important role in the contribution of ASIC3 to nociception and mechanosensation [7].
  • The acid-sensing ion channel-3 (ASIC3) is a degenerin/epithelial sodium channel expressed in the peripheral nervous system [7].

Biological context of ACCN3


Anatomical context of ACCN3


Associations of ACCN3 with chemical compounds

  • The sensitivity to pH or amiloride of single versus co-expressed ASIC subunits was not significantly different; however, gadolinium ions inhibited ASIC3 and ASIC2a+3 responses with much higher potency (IC(50) approximately 40 microm) than the ASIC2a response (IC(50) >/=1 mm) [12].
  • Here, we show that ASIC3 (acid-sensing ion channel #3) has the appropriate expression pattern and physical properties to be the detector of this lactic acid [4].
  • Moreover, both extracellular lactate and extracellular ATP increase the sensitivity of ASIC3 to protons [4].
  • Finally, the effect of lidocaine on pain and ASIC3 expression in the disc herniation model was examined [11].

Other interactions of ACCN3


Analytical, diagnostic and therapeutic context of ACCN3

  • We describe here the molecular cloning of a novel human proton receptor, hASIC3, a 531-amino acid-long subunit homologous to rat DRASIC [8].
  • 0. Immunoassays showed that both ASIC3 and CFTR proteins were expressed and co-immunoprecipitated mutually in Calu-3 cells [2].
  • Retrogradely labelled dorsal root ganglion neurons were subjected to triple-labelling immunohistochemistry using antisera against TRPV1, ASIC3 and neurofilament 68 (marker for myelinated neurons), and their soma diameter was measured [18].
  • Circular dichroism spectra of BcIII and BcIV show a high content of beta-strand secondary structure in both peptides, very similar to type 1 sodium channel toxins from various sea anemones, and to APETx1 and APETx2 from A. elegantissima, a HERG channel modulator and an ASIC3 inhibitor, respectively [19].


  1. The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons. Anzai, N., Deval, E., Schaefer, L., Friend, V., Lazdunski, M., Lingueglia, E. J. Biol. Chem. (2002) [Pubmed]
  2. Interregulation of Proton-gated Na+ Channel 3 and Cystic Fibrosis Transmembrane Conductance Regulator. Su, X., Li, Q., Shrestha, K., Cormet-Boyaka, E., Chen, L., Smith, P.R., Sorscher, E.J., Benos, D.J., Matalon, S., Ji, H.L. J. Biol. Chem. (2006) [Pubmed]
  3. Strong modulation by RFamide neuropeptides of the ASIC1b/3 heteromer in competition with extracellular calcium. Chen, X., Paukert, M., Kadurin, I., Pusch, M., Gründer, S. Neuropharmacology (2006) [Pubmed]
  4. An acid-sensing ion channel that detects ischemic pain. Naves, L.A., McCleskey, E.W. Braz. J. Med. Biol. Res. (2005) [Pubmed]
  5. Sustained currents through ASIC3 ion channels at the modest pH changes that occur during myocardial ischemia. Yagi, J., Wenk, H.N., Naves, L.A., McCleskey, E.W. Circ. Res. (2006) [Pubmed]
  6. A role for ASIC3 in the modulation of high-intensity pain stimuli. Chen, C.C., Zimmer, A., Sun, W.H., Hall, J., Brownstein, M.J., Zimmer, A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  7. PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current. Hruska-Hageman, A.M., Benson, C.J., Leonard, A.S., Price, M.P., Welsh, M.J. J. Biol. Chem. (2004) [Pubmed]
  8. Molecular cloning and regional distribution of a human proton receptor subunit with biphasic functional properties. Babinski, K., Lê, K.T., Séguéla, P. J. Neurochem. (1999) [Pubmed]
  9. Identification, functional expression and chromosomal localisation of a sustained human proton-gated cation channel. de Weille, J.R., Bassilana, F., Lazdunski, M., Waldmann, R. FEBS Lett. (1998) [Pubmed]
  10. Characterisation of DRASIC in the mouse inner ear. Hildebrand, M.S., de Silva, M.G., Klockars, T., Rose, E., Price, M., Smith, R.J., McGuirt, W.T., Christopoulos, H., Petit, C., Dahl, H.H. Hear. Res. (2004) [Pubmed]
  11. Up-regulation of acid-sensing ion channel 3 in dorsal root ganglion neurons following application of nucleus pulposus on nerve root in rats. Ohtori, S., Inoue, G., Koshi, T., Ito, T., Doya, H., Saito, T., Moriya, H., Takahashi, K. Spine (2006) [Pubmed]
  12. Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+. Babinski, K., Catarsi, S., Biagini, G., Séguéla, P. J. Biol. Chem. (2000) [Pubmed]
  13. Functional properties and pharmacological inhibition of ASIC channels in the human SJ-RH30 skeletal muscle cell line. Gitterman, D.P., Wilson, J., Randall, A.D. J. Physiol. (Lond.) (2005) [Pubmed]
  14. Molecular cloning of a DEG/ENaC sodium channel cDNA from human testis. Ishibashi, K., Marumo, F. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  15. Identification of acid-sensing ion channels in bone. Jahr, H., van Driel, M., van Osch, G.J., Weinans, H., van Leeuwen, J.P. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  16. Vanilloid receptor activation by 2- and 10-microm particles induces responses leading to apoptosis in human airway epithelial cells. Agopyan, N., Bhatti, T., Yu, S., Simon, S.A. Toxicol. Appl. Pharmacol. (2003) [Pubmed]
  17. Acid-sensing ionic channels in the rat vestibular endorgans and ganglia. Mercado, F., López, I.A., Acuna, D., Vega, R., Soto, E. J. Neurophysiol. (2006) [Pubmed]
  18. Spinal afferent neurons projecting to the rat lung and pleura express acid sensitive channels. Groth, M., Helbig, T., Grau, V., Kummer, W., Haberberger, R.V. Respir. Res. (2006) [Pubmed]
  19. BcIV, a new paralyzing peptide obtained from the venom of the sea anemone Bunodosoma caissarum. A comparison with the Na(+) channel toxin BcIII. Oliveira, J.S., Zaharenko, A.J., Ferreira, W.A., Konno, K., Shida, C.S., Richardson, M., L??cio, A.D., Beir??o, P.S., de Freitas, J.C. Biochim. Biophys. Acta (2006) [Pubmed]
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