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Gene Review

CDKN2AIP  -  CDKN2A interacting protein

Homo sapiens

Synonyms: CARF, CDKN2A-interacting protein, Collaborator of ARF, FLJ20036
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Disease relevance of CDKN2AIP

  • CVVHD is an effective treatment of choice applicable to all critically ill unstable patients with CARF [1].

High impact information on CDKN2AIP

  • Regions of LOH were further evaluated by studying two candidate tumor suppressor genes, hCDC4 and CARF, located within them [2].
  • However, sequencing of the coding regions of CARF and hCDC4 at 4q35 and 4q31, respectively, did not identify mutations [2].
  • CARF regulates p19ARF-p53-p21WAF1 senescence pathway by multiple checkpoints [3].
  • The Commission on Accreditation of Rehabilitation Facilities (CARF) requires that brain and spinal cord injury (SCI) specialty programs assure a base competency level for staff [4].

Biological context of CDKN2AIP

  • LOH was observed in 53, 40, 32, 38, and 27% of tumors at positions D4S1554 (the locus of CARF), D4S1572, D4S1548, D4S2934, and D4S3021, respectively [2].

Regulatory relationships of CDKN2AIP

  • We provide evidence that CARF plays a dual role in regulating p53-mediated senescence and apoptosis, the two major tumor suppressor mechanisms [5].

Analytical, diagnostic and therapeutic context of CDKN2AIP

  • SETTING: Randomly selected institutions accredited with the Commission on the Accreditation of Rehabilitation Facilities (CARF) [6].
  • In 59 of these cases of bilateral mastectomy in which a prophylactic contralateral mastectomy had been performed, 15% showed carcinoma of the opposite breast and 22% showed CARF [7].


  1. Continuous veno-venous hemodialysis (CVVHD) in the management of complicated renal failure. Sang, Y.Y., Uldall, P.R., Blake, P., Francoeur, R., Hall, E., Besley, M. Le Journal CANNT = CANNT journal : the journal of the Canadian Association of Nephrology Nurses and Technicians. (1990) [Pubmed]
  2. Mutational and LOH analyses of the chromosome 4q region in esophageal adenocarcinoma. Sterian, A., Kan, T., Berki, A.T., Mori, Y., Olaru, A., Schulmann, K., Sato, F., Wang, S., Paun, B., Cai, K., Hamilton, J.P., Abraham, J.M., Meltzer, S.J. Oncology (2006) [Pubmed]
  3. CARF regulates p19ARF-p53-p21WAF1 senescence pathway by multiple checkpoints. Kaul, S.C., Hasan, K., Wadhwa, R. Ann. N. Y. Acad. Sci. (2006) [Pubmed]
  4. Developing and implementing transdisciplinary rehabilitation competencies. Browner, C.M., Bessire, G.D. SCI nursing : a publication of the American Association of Spinal Cord Injury Nurses. (2004) [Pubmed]
  5. CARF Is a vital dual regulator of cellular senescence and apoptosis. Hasan, K., Cheung, C., Kaul, Z., Shah, N., Sakaushi, S., Sugimoto, K., Oka, S., Kaul, S.C., Wadhwa, R. J. Biol. Chem. (2009) [Pubmed]
  6. A multifactorial study of age bias among rehabilitation professionals. Rybarczyk, B., Haut, A., Lacey, R.F., Fogg, L.F., Nicholas, J.J. Archives of physical medicine and rehabilitation. (2001) [Pubmed]
  7. The contralateral breast in ipsilateral breast carcinoma. Hoffman, E. South. Med. J. (1990) [Pubmed]
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