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MeSH Review


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Disease relevance of Mastectomy


Psychiatry related information on Mastectomy


High impact information on Mastectomy


Chemical compound and disease context of Mastectomy


Biological context of Mastectomy


Anatomical context of Mastectomy


Associations of Mastectomy with chemical compounds

  • PURPOSE: The objective of this study was to determine locoregional recurrence (LRR) patterns after mastectomy and doxorubicin-based chemotherapy to define subgroups of patients who might benefit from adjuvant irradiation [28].
  • It can be calculated that the finding of supranormal urinary testosterone shortly after mastectomy represents virtually a 100% risk of recurrence, in contrast to a recurrence rate of about 38% in women with normal testosterone excretion [17].
  • The authors performed a randomized, prospective study on the effect of DMSO on skin flap viability in patients undergoing mastectomy and inguinal lymphadenectomy [29].
  • Sections from mastectomy specimens of 29 female-to-male transsexuals who had prolonged androgen administration prior to surgery were examined using routine light microscopy and immunohistochemical techniques [30].
  • Of the 17 patients who would have required a mastectomy at initiation of treatment, 15 were suitable for breast conservation after anastrozole treatment [31].

Gene context of Mastectomy

  • The purpose of our study was to review the evidence for the efficacy of surveillance for early detection, bilateral prophylactic mastectomy, prophylactic oophorectomy and chemoprevention in preventing breast cancer and improving survival of BRCA1 or BRCA2 carriers [32].
  • IHC for ER-beta was also performed on sections of BrCA from 118 women who were treated with mastectomy and AHTT [33].
  • In multivariate analysis in the 74 metastatic cases VEGF did not show any significance in relation to disease-free interval and overall survival from the time of mastectomy and from the time of relapse, whereas N and PgR did (p ranging from 0.018 to 0.001) [34].
  • P-glycoprotein expression in the rescue mastectomy specimen has finally been identified as a significant predictor of patient survival [35].
  • By immunoblot, EGF receptors were consistently more abundant in tumor tissue than in adjacent nontumor tissue from the same mastectomy specimen (n = 7) [36].

Analytical, diagnostic and therapeutic context of Mastectomy


  1. Breast cancer after prophylactic bilateral mastectomy in women with a BRCA1 or BRCA2 mutation. Meijers-Heijboer, H., van Geel, B., van Putten, W.L., Henzen-Logmans, S.C., Seynaeve, C., Menke-Pluymers, M.B., Bartels, C.C., Verhoog, L.C., van den Ouweland, A.M., Niermeijer, M.F., Brekelmans, C.T., Klijn, J.G. N. Engl. J. Med. (2001) [Pubmed]
  2. Breast cancer risk after bilateral prophylactic oophorectomy in BRCA1 mutation carriers. Rebbeck, T.R., Levin, A.M., Eisen, A., Snyder, C., Watson, P., Cannon-Albright, L., Isaacs, C., Olopade, O., Garber, J.E., Godwin, A.K., Daly, M.B., Narod, S.A., Neuhausen, S.L., Lynch, H.T., Weber, B.L. J. Natl. Cancer Inst. (1999) [Pubmed]
  3. Radiotherapy-related lung fibrosis enhanced by tamoxifen. Bentzen, S.M., Skoczylas, J.Z., Overgaard, M., Overgaard, J. J. Natl. Cancer Inst. (1996) [Pubmed]
  4. Collagenase-1 complexes with alpha2-macroglobulin in the acute and chronic wound environments. Grinnell, F., Zhu, M., Parks, W.C. J. Invest. Dermatol. (1998) [Pubmed]
  5. A randomized study of the effects of single-dose gabapentin versus placebo on postoperative pain and morphine consumption after mastectomy. Dirks, J., Fredensborg, B.B., Christensen, D., Fomsgaard, J.S., Flyger, H., Dahl, J.B. Anesthesiology (2002) [Pubmed]
  6. The role of sentinel lymph node biopsy in women undergoing prophylactic mastectomy. Dupont, E.L., Kuhn, M.A., McCann, C., Salud, C., Spanton, J.L., Cox, C.E. Am. J. Surg. (2000) [Pubmed]
  7. Cancer screening and risk-reducing behaviors of women seeking genetic cancer risk assessment for breast and ovarian cancers. MacDonald, D.J., Sarna, L., Uman, G.C., Grant, M., Weitzel, J.N. Oncology nursing forum. (2006) [Pubmed]
  8. Prophylactic mastectomy for women with BRCA1 and BRCA2 mutations--facts and controversy. Eisen, A., Weber, B.L. N. Engl. J. Med. (2001) [Pubmed]
  9. Mastectomy and oophorectomy by menstrual cycle phase in women with operable breast cancer. Love, R.R., Duc, N.B., Dinh, N.V., Shen, T.Z., Havighurst, T.C., Allred, D.C., DeMets, D.L. J. Natl. Cancer Inst. (2002) [Pubmed]
  10. Serum sialyltransferase and 5'-nucleotidase as reliable biomarkers in women with breast cancer. Dao, T.L., Ip, C., Patel, J. J. Natl. Cancer Inst. (1980) [Pubmed]
  11. Biallelic expression of the IGF2 gene in human breast disease. McCann, A.H., Miller, N., O'Meara, A., Pedersen, I., Keogh, K., Gorey, T., Dervan, P.A. Hum. Mol. Genet. (1996) [Pubmed]
  12. Prognostic value of extracapsular tumor spread for locoregional control in premenopausal patients with node-positive breast cancer treated with classical cyclophosphamide, methotrexate, and fluorouracil: long-term observations from International Breast Cancer Study Group Trial VI. Gruber, G., Bonetti, M., Nasi, M.L., Price, K.N., Castiglione-Gertsch, M., Rudenstam, C.M., Holmberg, S.B., Lindtner, J., Golouh, R., Collins, J., Crivellari, D., Carbone, A., Thürlimann, B., Simoncini, E., Fey, M.F., Gelber, R.D., Coates, A.S., Goldhirsch, A. J. Clin. Oncol. (2005) [Pubmed]
  13. Life expectancy gains from cancer prevention strategies for women with breast cancer and BRCA1 or BRCA2 mutations. Schrag, D., Kuntz, K.M., Garber, J.E., Weeks, J.C. JAMA (2000) [Pubmed]
  14. Randomized trial of observation versus adjuvant therapy with cyclophosphamide, fluorouracil, prednisone with or without tamoxifen following mastectomy in postmenopausal women with node-positive breast cancer. Ingle, J.N., Everson, L.K., Wieand, H.S., Martin, J.K., Votava, H.J., Wold, L.E., Krook, J.E., Cullinan, S.A., Paulsen, J.K., Twito, D.I. J. Clin. Oncol. (1988) [Pubmed]
  15. High complete remission rates with primary neoadjuvant infusional chemotherapy for large early breast cancer. Smith, I.E., Walsh, G., Jones, A., Prendiville, J., Johnston, S., Gusterson, B., Ramage, F., Robertshaw, H., Sacks, N., Ebbs, S. J. Clin. Oncol. (1995) [Pubmed]
  16. Automated quantitation of immunocytochemically localized estrogen receptors in human breast cancer. McClelland, R.A., Finlay, P., Walker, K.J., Nicholson, D., Robertson, J.F., Blamey, R.W., Nicholson, R.I. Cancer Res. (1990) [Pubmed]
  17. Paradoxical effects associated with supranormal urinary testosterone excretion in premenopausal women with breast cancer: increased risk of postmastectomy recurrence and higher remission rate after ovariectomy. Secreto, G., Zumoff, B. Cancer Res. (1983) [Pubmed]
  18. Degradation of fibronectin and vitronectin in chronic wound fluid: analysis by cell blotting, immunoblotting, and cell adhesion assays. Grinnell, F., Ho, C.H., Wysocki, A. J. Invest. Dermatol. (1992) [Pubmed]
  19. Heterogeneous versus homogeneous genetic nature of multiple foci of in situ carcinoma of the breast. Volante, M., Sapino, A., Croce, S., Bussolati, G. Hum. Pathol. (2003) [Pubmed]
  20. Differential expression of mucin genes in mammary and extramammary Paget's disease. Kuan, S.F., Montag, A.G., Hart, J., Krausz, T., Recant, W. Am. J. Surg. Pathol. (2001) [Pubmed]
  21. Analgesic efficacy of diclofenac in combination with morphine and paracetamol after mastectomy and immediate breast reconstruction. Legeby, M., Sandelin, K., Wickman, M., Olofsson, C. Acta anaesthesiologica Scandinavica. (2005) [Pubmed]
  22. HER-2/neu oncogene in uterine carcinosarcoma on tamoxifen therapy. Raspollini, M.R., Mecacci, F., Paglierani, M., Marchionni, M., Taddei, G.L. Pathol. Res. Pract. (2005) [Pubmed]
  23. Tumor necrosis factor alpha and interleukin 11 secreted by malignant breast epithelial cells inhibit adipocyte differentiation by selectively down-regulating CCAAT/enhancer binding protein alpha and peroxisome proliferator-activated receptor gamma: mechanism of desmoplastic reaction. Meng, L., Zhou, J., Sasano, H., Suzuki, T., Zeitoun, K.M., Bulun, S.E. Cancer Res. (2001) [Pubmed]
  24. Serum prolactin after chest wall surgery: elevated levels after mastectomy. Herman, V., Kalk, W.J., de Moor, N.G., Levin, J. J. Clin. Endocrinol. Metab. (1981) [Pubmed]
  25. Aromatase activity and interleukin-6 production by normal and malignant breast tissues. Purohit, A., Ghilchik, M.W., Duncan, L., Wang, D.Y., Singh, A., Walker, M.M., Reed, M.J. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  26. Intraepidermal cytokeratin 7 expression is not restricted to Paget cells but is also seen in Toker cells and Merkel cells. Lundquist, K., Kohler, S., Rouse, R.V. Am. J. Surg. Pathol. (1999) [Pubmed]
  27. Post-mastectomy radiotherapy following adjuvant chemotherapy and autologous bone marrow transplantation for breast cancer patients with greater than or equal to 10 positive axillary lymph nodes. Cancer and Leukemia Group B. Marks, L.B., Halperin, E.C., Prosnitz, L.R., Ross, M., Vredenburgh, J.J., Rosner, G.L., Peters, W. Int. J. Radiat. Oncol. Biol. Phys. (1992) [Pubmed]
  28. Locoregional recurrence patterns after mastectomy and doxorubicin-based chemotherapy: implications for postoperative irradiation. Katz, A., Strom, E.A., Buchholz, T.A., Thames, H.D., Smith, C.D., Jhingran, A., Hortobagyi, G., Buzdar, A.U., Theriault, R., Singletary, S.E., McNeese, M.D. J. Clin. Oncol. (2000) [Pubmed]
  29. Improved outcome of surgical flaps treated with topical dimethylsulfoxide. Rand-Luby, L., Pommier, R.F., Williams, S.T., Woltering, E.A., Small, K.A., Fletcher, W.S. Ann. Surg. (1996) [Pubmed]
  30. An immunohistochemical study of the long-term effects of androgen administration on female-to-male transsexual breast: a comparison with normal female breast and male breast showing gynaecomastia. Burgess, H.E., Shousha, S. J. Pathol. (1993) [Pubmed]
  31. The effects of neoadjuvant anastrozole (Arimidex) on tumor volume in postmenopausal women with breast cancer: a randomized, double-blind, single-center study. Dixon, J.M., Renshaw, L., Bellamy, C., Stuart, M., Hoctin-Boes, G., Miller, W.R. Clin. Cancer Res. (2000) [Pubmed]
  32. Prevention of breast cancer in women who carry BRCA1 or BRCA2 mutations: a critical review of the literature. Calderon-Margalit, R., Paltiel, O. Int. J. Cancer (2004) [Pubmed]
  33. Estrogen receptor beta expression in invasive breast cancer. Mann, S., Laucirica, R., Carlson, N., Younes, P.S., Ali, N., Younes, A., Li, Y., Younes, M. Hum. Pathol. (2001) [Pubmed]
  34. Vascular endothelial growth factor (VEGF) and other common tissue prognostic indicators in breast cancer: a case-control study. Nicolini, A., Campani, D., Miccoli, P., Spinelli, C., Carpi, A., Menicagli, M., Ferrari, P., Gadducci, G., Rossi, G., Fini, M., Giavaresi, G., Bonazzi, V., Giardino, R. Int. J. Biol. Markers (2004) [Pubmed]
  35. Expression of LRP and MDR1 in locally advanced breast cancer predicts axillary node invasion at the time of rescue mastectomy after induction chemotherapy. Schneider, J., Gonzalez-Roces, S., Pollán, M., Lucas, R., Tejerina, A., Martin, M., Alba, A. Breast Cancer Res. (2001) [Pubmed]
  36. Epidermal growth factor receptors in human breast carcinoma cells: a potential selective target for transforming growth factor alpha-Pseudomonas exotoxin 40 fusion protein. Arteaga, C.L., Hurd, S.D., Dugger, T.C., Winnier, A.R., Robertson, J.B. Cancer Res. (1994) [Pubmed]
  37. Decision analysis--effects of prophylactic mastectomy and oophorectomy on life expectancy among women with BRCA1 or BRCA2 mutations. Schrag, D., Kuntz, K.M., Garber, J.E., Weeks, J.C. N. Engl. J. Med. (1997) [Pubmed]
  38. Determination of silicon in breast and capsular tissue from patients with breast implants performed by inductively coupled plasma emission spectroscopy. Comparison with tissue histology. McConnell, J.P., Moyer, T.P., Nixon, D.E., Schnur, P.L., Salomao, D.R., Crotty, T.B., Weinzweig, J., Harris, J.B., Petty, P.M. Am. J. Clin. Pathol. (1997) [Pubmed]
  39. Local-regional recurrence in breast cancer after mastectomy and adriamycin-based adjuvant chemotherapy: evaluation of the role of postoperative radiotherapy. Sykes, H.F., Sim, D.A., Wong, C.J., Cassady, J.R., Salmon, S.E. Int. J. Radiat. Oncol. Biol. Phys. (1989) [Pubmed]
  40. Effectiveness of mastectomy by response to induction chemotherapy for control in inflammatory breast carcinoma. Fleming, R.Y., Asmar, L., Buzdar, A.U., McNeese, M.D., Ames, F.C., Ross, M.I., Singletary, S.E. Ann. Surg. Oncol. (1997) [Pubmed]
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