Disease relevance of BTBD7

• Naturally acquired immunity against Plasmodium falciparum malaria was analysed by immunoprecipitation and electrophoretic analysis of FUP-1 strain antigens by sera from individuals with different histories of exposure to malaria [1].

High impact information on BTBD7

• Furthermore, cell proliferation enhancing activity of fup1 was shown by MTT assay in stable transfectant NIH3T3 cell line with pcDNA3-derived plasmid having fup1 under the regulation of pCMV, while cell proliferation repressing activity of antisense fup1 was observed in BEL7404 stable transfectant cells [2].
• FUP1, a gene associated with hepatocellular carcinoma, stimulates NIH3T3 cell proliferation and tumor formation in nude mice [2].
• The cDNA of fup1 has an open-reading frame 1233 base pairs in size [2].
• Although no genotypic variation was detected for four polymorphic loci compared to the original FUP-1 parasite population, FUP-2-infected erythrocytes exhibit little or no detectable surface determinants, including those reacting with antibodies raised against FUP-1 surface antigens [3].
• Analysis of the reactivity of adult sera from different parts of the world with FUP-1 antigens showed that there were no major geographically restricted antibody specificities [1].

References