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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

EXOC1  -  exocyst complex component 1

Homo sapiens

Synonyms: BM-012, BM-102, Exocyst complex component 1, Exocyst complex component Sec3, FLJ10893, ...
 
 
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Disease relevance of EXOC1

  • We report here the crystal structures of the beta-chain of a TCR complexed with the Staphylococcus aureus enterotoxins C2 and C3 (SEC2, SEC3) [1].
  • We have identified a human adenocarcinoma cell line, SW480, that assists in the activation of human T cells by the staphylococcal enterotoxins B (SEB), C1 (SEC1), and D (SED), but not SEA, SEC2, SEC3, or SEE [2].
  • Sodium dodecyl sulfate-polyacrylamide gel electrophoresis also revealed preferences in the binding of other SE such as SED, SEE and toxic shock syndrome toxin 1 to DR-like molecules, SEC2 to HLA-DQ-like molecules and SEC3 to DR- and DQ-like molecules [3].
  • Cytokine induction by Mycoplasma arthritidis-derived superantigen (MAS), but not by TSST-1 or SEC-3, is correlated to certain HLA-DR types [4].
  • BioMarin is developing Aryplase (BM-102), a recombinant form of the enzyme N-acetylgalactosamine 4-sulfatase, for the potential treatment of mucopolysaccharidosis type VI (Maroteaux-Lamy Syndrome) [5].
 

High impact information on EXOC1

  • The three-dimensional structure of the complex between a T cell receptor (TCR) beta chain (mouse Vbeta8.2Jbeta2.1Cbeta1) and the superantigen (SAG) staphylococcal enterotoxin C3 (SEC3) has been recently determined to 3.5 resolution [6].
  • Alkyl chains in SEC-2 are disordered, but SEC-3 is indicative of well-ordered alkyl chains [7].
  • We synthesized two surfactant-encapsulated polyoxometalate (POM) clusters (SECs), (DODA)(15)[H(3)Mo(57)V(6)(NO)(6)O(189)(H(2)O)(12)(VO)(6)].13H(2)O (SEC-2, DODA: dimethyldioctadecyl ammonium) and (DODA)(12)[Eu(H(2)O)P(5)W(30)O(110)].28H(2)O (SEC-3) [7].
  • The p-T1 tumors were subdivided into three categories: carcinoma limited to the lamina propria mucosae (19 patients, SEC1), carcinoma invading the lamina muscularis mucosae or with invasion just into the submucosa (27 patients, SEC2), and carcinoma definitely invading the submucosa (44 patients, SEC3) [8].
 

Anatomical context of EXOC1

  • Staphylococcal enterotoxins SEB and SEC3 and toxic shock syndrome toxin TSST-1 act as superantigens by overstimulating the human immune system and thereby compromise host defense [9].
 

Associations of EXOC1 with chemical compounds

  • C3 (SEC3) an even more pronounced difference between patients' and controls' T cells could be observed (10 ng/ml p < 0.002, 1 ng/ml p < 0.0005) [10].
 

Analytical, diagnostic and therapeutic context of EXOC1

References

  1. Crystal structure of a T-cell receptor beta-chain complexed with a superantigen. Fields, B.A., Malchiodi, E.L., Li, H., Ysern, X., Stauffacher, C.V., Schlievert, P.M., Karjalainen, K., Mariuzza, R.A. Nature (1996) [Pubmed]
  2. Intercellular adhesion molecule-1 and leukocyte function-associated antigen-3 provide costimulation for superantigen-induced T lymphocyte proliferation in the absence of a specific presenting molecule. Lamphear, J.G., Stevens, K.R., Rich, R.R. J. Immunol. (1998) [Pubmed]
  3. Different staphylococcal enterotoxins bind preferentially to distinct major histocompatibility complex class II isotypes. Herrmann, T., Accolla, R.S., MacDonald, H.R. Eur. J. Immunol. (1989) [Pubmed]
  4. Cytokine induction by Mycoplasma arthritidis-derived superantigen (MAS), but not by TSST-1 or SEC-3, is correlated to certain HLA-DR types. Alvarez-Ossorio, L., Johannsen, M., Alvarez-Ossorio, R., Nicklas, W., Kirchner, H., Rink, L. Scand. J. Immunol. (1998) [Pubmed]
  5. Aryplase (Biomarin). Yogalingam, G. Current opinion in investigational drugs (London, England : 2000) (2004) [Pubmed]
  6. A mutational analysis of the binding of staphylococcal enterotoxins B and C3 to the T cell receptor beta chain and major histocompatibility complex class II. Leder, L., Llera, A., Lavoie, P.M., Lebedeva, M.I., Li, H., Sékaly, R.P., Bohach, G.A., Gahr, P.J., Schlievert, P.M., Karjalainen, K., Mariuzza, R.A. J. Exp. Med. (1998) [Pubmed]
  7. Polyoxometalates matrixed into surfactants: synthesis, characterizations, and conformations of surfactants. Bu, W., Wu, L., Tang, A.C. Journal of colloid and interface science. (2004) [Pubmed]
  8. Detection of lymph node metastasis using desmoglein 1 expression in superficial esophageal cancer in relation to the endoscopic mucosal resection. Nakano, S., Baba, M., Natsugoe, S., Kijima, F., Nakashima, S., Shimada, M., Shirao, K., Kusano, C., Yoshinaka, H., Fukumoto, T., Aikou, T. Dis. Esophagus (1998) [Pubmed]
  9. Modeling of receptor mimics that inhibit superantigen pathogenesis. Möllhoff, M., Zanden, H.B., Shiflett, P.R., Gupta, G. J. Mol. Recognit. (2005) [Pubmed]
  10. Activation of CVID patients' T cells with conventional antigens and superantigens. Fischer, M.B., Hauber, I., Eggenbauer, H., Thon, V., Lokaj, J., Wolf, H.M., Mannhalter, J.W., Eibl, M.M. Immunodeficiency (1993) [Pubmed]
  11. Staphylococcal enterotoxin-activated spleen cells passively transfer diabetes in BB/Wor rat. Ellerman, K.E., Like, A.A. Diabetes (1992) [Pubmed]
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