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Gene Review: 

CSGALNACT1  -  chondroitin sulfate N-acetylgalactosaminyl...

Homo sapiens

Synonyms: Beta4GalNAcT-1, CHGN, CSGalNAcT-1, ChGn, Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1, ...
 
 
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Disease relevance of ChGn

  • Baculovirus infection of the cells, however, resulted in a decrease in the activity of beta 4-GalNAcT from 80 to <1 pmol.min-1 mg-1 protein within 48 h post infection [1].
 

High impact information on ChGn

  • Moreover, Chinese hamster ovary CHO-Lec8 and CHO-Lec2 cells expressing Ce(beta)4GalNAcT acquired LDN determinants on endogenous glycoprotein N-glycans, demonstrating that the enzyme is active in mammalian cells as an authentic beta4GalNAcT [2].
  • Lepidopteran insect cell lines derived from Trichoplusia ni, Spodoptera frugiperda, and Mamestra brassicae were found to express a beta 1-->4- N-acetylgalactosaminyltransferase (beta 4-GalNAcT) that catalyzes the transfer of GalNAc from UDP-GalNAc to oligosaccharides and glycoproteins carrying a terminal beta-linked GlcNAc residue [1].
  • It is proposed that the schistosome beta 4-GalNAcT functions in the expression of specific carbohydrate structures that contribute to a molecular mimicry, enabling the schistosome to evade the defence system of the snail host [3].
 

Analytical, diagnostic and therapeutic context of ChGn

  • Examined were 34 patients with chgn (Group I), 50 patients with a stable allograft function (Group II), and 25 healthy subjects (control) [4].

References

  1. Glycosylation in lepidopteran insect cells: identification of a beta 1-->4-N-acetylgalactosaminyltransferase involved in the synthesis of complex-type oligosaccharide chains. van Die, I., van Tetering, A., Bakker, H., van den Eijnden, D.H., Joziasse, D.H. Glycobiology (1996) [Pubmed]
  2. Molecular cloning and enzymatic characterization of a UDP-GalNAc:GlcNAc(beta)-R beta1,4-N-acetylgalactosaminyltransferase from Caenorhabditis elegans. Kawar, Z.S., Van Die, I., Cummings, R.D. J. Biol. Chem. (2002) [Pubmed]
  3. Identification and characterization of a UDP-GalNAc:GlcNAc beta-R beta 1-->4-N-acetylgalactosaminyltransferase from cercariae of the schistosome Trichobilharzia ocellata. Catalysis of a key step in the synthesis of N,N'-diacetyllactosediamino (lacdiNAc)-type glycans. Neeleman, A.P., van der Knaap, W.P., van den Eijnden, D.H. Glycobiology (1994) [Pubmed]
  4. Urine excretion of transforming growth factor-beta1 in chronic allograft nephropathy. Boratyńska, M. Ann. Transplant. (1999) [Pubmed]
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