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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

WSB2  -  WD repeat and SOCS box containing 2

Homo sapiens

Synonyms: CS box-containing WD protein, MGC10210, SBA2, WD repeat and SOCS box-containing protein 2, WSB-2
 
 
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Disease relevance of WSB2

 

High impact information on WSB2

  • We have carried out a percolation analysis of the adsorption of ethane and nitrogen in SBA-2, a structured mesoporous silica consisting of a hexagonal close-packed (hcp) array of spherical cavities connected by cylindrical channels [2].
  • AIM: To investigate SBA2 expression in CRC cell lines and surgical specimens of CRC and autologous healthy mucosa [1].
  • Of the 9 cases with lymph nodes affected, 78% (7/9) had reduced SBA2 mRNA expression in contrast to 24% (5/21) in non-metastasis samples 0.01>P<0.05) [1].
 

Analytical, diagnostic and therapeutic context of WSB2

  • METHODS: Reverse transcription-polymerase chain reaction (RT-PCR) was used for relative quantification of SBA2 mRNA levels in 4 human CRC cell lines with different grades of differentiation and 30 clinical samples [1].

References

  1. Differential expression of a novel colorectal cancer differentiation-related gene in colorectal cancer. Li, X.G., Song, J.D., Wang, Y.Q. World J. Gastroenterol. (2001) [Pubmed]
  2. Structure of the mesoporous silica SBA-2, determined by a percolation analysis of adsorption. Pérez-Mendoza, M., Gonzalez, J., Wright, P.A., Seaton, N.A. Langmuir : the ACS journal of surfaces and colloids. (2004) [Pubmed]
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