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Gene Review

Rassf1  -  Ras association (RalGDS/AF-6) domain...

Mus musculus

Synonyms: 123F protein, 123F2, AA536941, AU044980, NORE2A, ...
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High impact information on Rassf1


Biological context of Rassf1


Associations of Rassf1 with chemical compounds

  • Additional mutation of tyrosine 992 to phenylalanine in the truncated receptor mutant (Dc-123F) further decreased the receptor internalization rate to a minimal level (ke = 0.07-0.10/min), equivalent to the ke measured for cells expressing kinase-negative receptor (A721) [3].
  • Two mutants, F5, in which all five tyrosine autophosphorylation sites substituted by phenylalanine, and Dc 123F, in which four tyrosines were removed by deletion and the fifth (Tyr-992) was mutated into phenylalanine, phosphorylated eps8 and eps15 as efficiently as the wild-type receptor [4].


  1. The RASSF1A isoform of RASSF1 promotes microtubule stability and suppresses tumorigenesis. van der Weyden, L., Tachibana, K.K., Gonzalez, M.A., Adams, D.J., Ng, B.L., Petty, R., Venkitaraman, A.R., Arends, M.J., Bradley, A. Mol. Cell. Biol. (2005) [Pubmed]
  2. Cre-loxP chromosome engineering of a targeted deletion in the mouse corresponding to the 3p21.3 region of homozygous loss in human tumours. Smith, A.J., Xian, J., Richardson, M., Johnstone, K.A., Rabbitts, P.H. Oncogene (2002) [Pubmed]
  3. Multiple autophosphorylation sites of the epidermal growth factor receptor are essential for receptor kinase activity and internalization. Contrasting significance of tyrosine 992 in the native and truncated receptors. Sorkin, A., Helin, K., Waters, C.M., Carpenter, G., Beguinot, L. J. Biol. Chem. (1992) [Pubmed]
  4. Structural requirements of the epidermal growth factor receptor for tyrosine phosphorylation of eps8 and eps15, substrates lacking Src SH2 homology domains. Alvarez, C.V., Shon, K.J., Miloso, M., Beguinot, L. J. Biol. Chem. (1995) [Pubmed]
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