The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SUCNR1  -  succinate receptor 1

Homo sapiens

Synonyms: G-protein coupled receptor 91, GPR91, P2Y purinoceptor 1-like, Succinate receptor 1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SUCNR1


High impact information on SUCNR1

  • All known P2Y receptors (i.e. P2Y(1,2,4,6,11,12,13,14)) and two P2Y-like receptors (GPR91 and GPR17) were detected in all subjects [2].
  • We also report that GPR99 (ref. 4), a close relative of GPR91, responds to alpha-ketoglutarate, another intermediate in the citric acid cycle [1].
  • The succinate-induced hypertensive effect involves the renin-angiotensin system and is abolished in GPR91-deficient mice [1].
  • Here we show that GPR91 (ref. 3), a previously orphan G-protein-coupled receptor (GPCR), functions as a receptor for the citric acid cycle intermediate succinate [1].


  1. Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors. He, W., Miao, F.J., Lin, D.C., Schwandner, R.T., Wang, Z., Gao, J., Chen, J.L., Tian, H., Ling, L. Nature (2004) [Pubmed]
  2. P2 receptors in human heart: upregulation of P2X6 in patients undergoing heart transplantation, interaction with TNFalpha and potential role in myocardial cell death. Banfi, C., Ferrario, S., De Vincenti, O., Ceruti, S., Fumagalli, M., Mazzola, A., D' Ambrosi, N., Volontè, C., Fratto, P., Vitali, E., Burnstock, G., Beltrami, E., Parolari, A., Polvani, G., Biglioli, P., Tremoli, E., Abbracchio, M.P. J. Mol. Cell. Cardiol. (2005) [Pubmed]
WikiGenes - Universities