The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Cym  -  chymosin

Rattus norvegicus

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on LOC56825

  • A phylogenetic tree based on nucleotide sequences showed clearly that pepsinogens fall into four major groups, namely prochymosin and pepsinogen F of the neonate/infant and pepsinogens A and C of adult animals [1].
  • Northern blot analysis confirmed that genes for prochymosin and pepsinogen F are expressed only at neonatal/infant stages and the switching of gene expression to that of pepsinogen C occurred at late infant stages [1].
  • Molecular cloning of rat prochymosin cDNA was achieved along with cDNA for another neonate-specific pepsinogen, pepsinogen F, although determination of pepsinogen F in neonatal gastric mucosa was unsuccessful, presumably due to its lack of proteolytic activity or different proteolytic specificity [1].
 

Analytical, diagnostic and therapeutic context of LOC56825

  • To investigate the role of the 21-24 (pepsin numbering) loop in prochymosin, the amino acid residues GTPP at positions 21 through 24 were replaced with GG, the equivalent loop residues from its homologous protein, penicillopepsin, or SG, GS by site-directed mutagenesis [2].

References

  1. Molecular cloning of neonate/infant-specific pepsinogens from rat stomach mucosa and their expressional change during development. Kageyama, T., Ichinose, M., Tsukada-Kato, S., Omata, M., Narita, Y., Moriyama, A., Yonezawa, S. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  2. Functional implications of the 21-24 loop in recombinant prochymosin. Li, H., Zhang, Y., Dong, Y., Yang, K. Biochim. Biophys. Acta (1998) [Pubmed]
 
WikiGenes - Universities