Disease relevance of TCEAL7

• These data implicate TCEAL7 as a cell death regulatory protein that is frequently inactivated in ovarian cancers, and suggest that it may function as a tumor suppressor [1].

High impact information on TCEAL7

• Finally, re-expression of TCEAL7 in cancer cell lines induces cell death and reduces colony formation efficiency [1].
• Here we report on the cloning of a novel candidate tumor suppressor gene TCEAL7 inactivated by methylation in ovarian cancer [1].
• Epigenetic silencing of TCEAL7 (Bex4) in ovarian cancer [1].
• Sequence analyses of bisufite-modified genomic DNA from somatic cell hybrids with either the active or the inactive human X chromosome reveal that TCEAL7 is subjected to X chromosome inactivation [1].
• This report focuses on the elucidation of mechanisms associated with TCEAL7 downregulation [1].

Biological context of TCEAL7

• Loss of TCEAL7 expression in primary tumors and cell lines correlates with methylation of a CpG site within the promoter [1].

Associations of TCEAL7 with chemical compounds

• Expression of TCEAL7 is downregulated in a majority of ovarian tumors and cancer cell lines but induced by 5-aza-2'-deoxycytidine treatment in a dose-dependant manner, implicating methylation as a mechanism of TCEAL7 inactivation [1].

References