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Gene Review

XAB2  -  XPA binding protein 2

Homo sapiens

Synonyms: HCNP, HCRN, KIAA1177, NTC90, PP3898, ...
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Disease relevance of XAB2

  • Knockdown of XAB2 with small interfering RNA in HeLa cells resulted in a hypersensitivity to killing by UV light and a decreased recovery of RNA synthesis after UV irradiation and regular RNA synthesis [1].

High impact information on XAB2


  1. Isolation of XAB2 complex involved in pre-mRNA splicing, transcription, and transcription-coupled repair. Kuraoka, I., Ito, S., Wada, T., Hayashida, M., Lee, L., Saijo, M., Nakatsu, Y., Matsumoto, M., Matsunaga, T., Handa, H., Qin, J., Nakatani, Y., Tanaka, K. J. Biol. Chem. (2008) [Pubmed]
  2. XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription. Nakatsu, Y., Asahina, H., Citterio, E., Rademakers, S., Vermeulen, W., Kamiuchi, S., Yeo, J.P., Khaw, M.C., Saijo, M., Kodo, N., Matsuda, T., Hoeijmakers, J.H., Tanaka, K. J. Biol. Chem. (2000) [Pubmed]
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