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Gene Review:

XAB2 - XPA binding protein 2

Homo sapiens

Synonyms: HCNP, HCRN, KIAA1177, NTC90, PP3898, ...

Nakatsu, Y. et al., Kuraoka, I. et al.

Isao Kuraoka, Shinsuke Ito, Tadashi Wada, Mika Hayashida, Lily Lee, Masafumi Saijo, Yoshimichi Nakatsu, Megumi Matsumoto, Tsukasa Matsunaga, Hiroshi Handa, Jun Qin, Yoshihiro Nakatani, Kiyoji Tanaka,

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Disease relevance of XAB2

Knockdown of XAB2 with small interfering RNA in HeLa cells resulted in a hypersensitivity to killing by UV light and a decreased recovery of RNA synthesis after UV irradiation and regular RNA synthesis [1].

High impact information on XAB2

Here we report the identification of a novel protein designated XAB2 (XPA-binding protein 2) that was identified by virtue of its ability to interact with XPA, a factor central to both nucleotide excision repair subpathways [2].
XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription [2].
Furthermore, antibodies against XAB2 inhibited both transcription-coupled repair and transcription in vivo but not global genome repair when microinjected into living fibroblasts [2].

References

Isolation of XAB2 complex involved in pre-mRNA splicing, transcription, and transcription-coupled repair. Kuraoka, I., Ito, S., Wada, T., Hayashida, M., Lee, L., Saijo, M., Nakatsu, Y., Matsumoto, M., Matsunaga, T., Handa, H., Qin, J., Nakatani, Y., Tanaka, K. J. Biol. Chem. (2008) [Pubmed]
XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription. Nakatsu, Y., Asahina, H., Citterio, E., Rademakers, S., Vermeulen, W., Kamiuchi, S., Yeo, J.P., Khaw, M.C., Saijo, M., Kodo, N., Matsuda, T., Hoeijmakers, J.H., Tanaka, K. J. Biol. Chem. (2000) [Pubmed]

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AgaP_AGAP012369	Anopheles gambiae str. PEST
AT5G28740	Arabidopsis thaliana
XAB2	Bos taurus
C50F2.3	Caenorhabditis elegans
XAB2	Canis lupus familiaris
xab2	Danio rerio
fand	Drosophila melanogaster
XAB2	Macaca mulatta
MGG_07087	Magnaporthe oryzae 70-15
Xab2	Mus musculus
NCU08036	Neurospora crassa OR74A
Os07g0644300	Oryza sativa Japonica Group
XAB2	Pan troglodytes
Xab2	Rattus norvegicus
cwf3	Schizosaccharomyces pombe 972h-
xab2	Xenopus (Silurana) tropicalis

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