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Gene Review:

TRIM54 - tripartite motif containing 54

Homo sapiens

Synonyms: MURF, MURF-3, MURF3, MuRF, MuRF-3, ...

Gregorio, C.C. et al., van der Spek, H. et al., Shaw, J.M. et al., Blum, B. et al.

Gregorio, Perry, McElhinny,

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High impact information on TRIM54

Maxicircle-encoded guide RNAs (gRNAs) for cytochrome b and maxicircle unidentified reading frames 2 and 3 (MURF2 and MURF3) were isolated by hybrid selection and sequenced [1].
Uridine additions and deletions in the 5' ends of the COIII, MURF2, and MURF3 transcripts create new N-terminal amino acid sequences that are conserved between species, and new AUG initiation codons in several cases [2].
To increase our understanding of the mechanism of this process we have compared the nucleotide sequence of the frameshifted mitochondrial MURF3 gene from Crithidia fasciculata to that of a large number of MURF3 cDNAs [3].
Finally, MURF-3 is developmentally upregulated, associates with microtubules, the sarcomeric M-line (this report) and Z-line, and is required for microtubule stability and myogenesis [4].
Functional properties of the titin/connectin-associated proteins, the muscle-specific RING finger proteins (MURFs), in striated muscle [4].

Anatomical context of TRIM54

Recently, the muscle specific RING finger (MURF) family members have established themselves as excellent candidates for linking myofibril components (including the giant, multi-functional protein, titin/connectin), with microtubules, intermediate filaments, and nuclear factors [4].

References

Guide RNAs in kinetoplastid mitochondria have a nonencoded 3' oligo(U) tail involved in recognition of the preedited region. Blum, B., Simpson, L. Cell (1990) [Pubmed]
Editing of kinetoplastid mitochondrial mRNAs by uridine addition and deletion generates conserved amino acid sequences and AUG initiation codons. Shaw, J.M., Feagin, J.E., Stuart, K., Simpson, L. Cell (1988) [Pubmed]
Transcripts from the frameshifted MURF3 gene from Crithidia fasciculata are edited by U insertion at multiple sites. van der Spek, H., van den Burg, J., Croiset, A., van den Broek, M., Sloof, P., Benne, R. EMBO J. (1988) [Pubmed]
Functional properties of the titin/connectin-associated proteins, the muscle-specific RING finger proteins (MURFs), in striated muscle. Gregorio, C.C., Perry, C.N., McElhinny, A.S. J. Muscle Res. Cell. Motil. (2005) [Pubmed]

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