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Gene Review

Trim54  -  tripartite motif-containing 54

Mus musculus

Synonyms: 4930486E09Rik, 4930566I02Rik, MURF, MURF-3, MuRF, ...
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High impact information on Trim54

  • Regulation of microtubule dynamics and myogenic differentiation by MURF, a striated muscle RING-finger protein [1].
  • The leucine-rich coiled-coil domain of MURF mediates association with microtubules, whereas the RING-finger domain is required for microtubule stabilization and an additional region is required for homo-oligomerization [1].
  • We describe a novel muscle-specific RING-finger protein (MURF) expressed specifically in cardiac and skeletal muscle cells throughout pre- and postnatal mouse development [1].
  • Expression of MURF is required for skeletal myoblast differentiation and myotube fusion [1].
  • MURF belongs to the RING-B-box-coiled-coil subclass of RING-finger proteins, characterized by an NH(2)-terminal RING-finger followed by a zinc-finger domain (B-box) and a leucine-rich coiled-coil domain [1].

Biological context of Trim54


Anatomical context of Trim54

  • Expression of MURF establishes a cellular microtubule network that is resistant to microtubule depolymerization induced by alkaloids, cold and calcium [1].

Other interactions of Trim54


  1. Regulation of microtubule dynamics and myogenic differentiation by MURF, a striated muscle RING-finger protein. Spencer, J.A., Eliazer, S., Ilaria, R.L., Richardson, J.A., Olson, E.N. J. Cell Biol. (2000) [Pubmed]
  2. Loss of muscle-specific RING-finger 3 predisposes the heart to cardiac rupture after myocardial infarction. Fielitz, J., van Rooij, E., Spencer, J.A., Shelton, J.M., Latif, S., van der Nagel, R., Bezprozvannaya, S., de Windt, L., Richardson, J.A., Bassel-Duby, R., Olson, E.N. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
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