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Gene Review

PTGER1  -  prostaglandin E receptor 1 (subtype EP1),...

Homo sapiens

Synonyms: EP1, PGE receptor EP1 subtype, PGE2 receptor EP1 subtype, Prostaglandin E2 receptor EP1 subtype, Prostanoid EP1 receptor
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High impact information on PTGER1

  • A change in intracellular localization was observed at term labor, where PTGER1 and PTGER4 were predominately associated with the nucleus [1].
  • The PTGER1, TBXA2R, and PTGIR genes mapped to chromosome 19 at positions 19p13.1, 19p13.3, and 19q13.3, respectively [2].
  • PGE2-mediated inhibition was not antagonized by the selective prostanoid EP1-receptor antagonists AH 6809 (10 microM) or SC-19220 (30 microM), nor did these agents alone affect basal or field-stimulated 3H-NE release [3].
  • Expression of the gene encoding the prostanoid EP1 receptor increased with advancing gestational age prior to labor (r2 = 0.8, P = 0.007) [4].


  1. Regional expression of prostaglandin E2 and F2alpha receptors in human myometrium, amnion, and choriodecidua with advancing gestation and labor. Grigsby, P.L., Sooranna, S.R., Adu-Amankwa, B., Pitzer, B., Brockman, D.E., Johnson, M.R., Myatt, L. Biol. Reprod. (2006) [Pubmed]
  2. Chromosomal localization of the human prostanoid receptor gene family. Duncan, A.M., Anderson, L.L., Funk, C.D., Abramovitz, M., Adam, M. Genomics (1995) [Pubmed]
  3. Prejunctional prostaglandin receptors in the human iris-ciliary body. Ohia, S.E., Jumblatt, J.E. Curr. Eye Res. (1991) [Pubmed]
  4. Effects of gestational age and labor on the expression of prostanoid receptor genes in pregnant baboon cervix. Smith, G.C., Wu, W.X., Nathanielsz, P.W. Prostaglandins Other Lipid Mediat. (2001) [Pubmed]
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