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Gene Review:

PTGER1 - prostaglandin E receptor 1 (subtype EP1),...

Bos taurus

Shibuya, I. et al., Mazar-Feldman, J. et al., de Brum-Fernandes, A.J. et al., Chagas, G.M. et al., Gould, S.F. et al., et al.

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High impact information on EP1

These studies were designed to determine whether this steroidogenic effect of PGE2 was mediated by an EP1, EP2, or EP3 receptor [1].
These results suggest that PGE2, acting on EP1-like receptors, induces Ca2+ release from ryanodine/caffeine-sensitive stores through a mechanism independent of IP3 and cAMP and that PGE2 may share the same mechanism with PACAP and the other peptide ligands in causing Ca2+ release in bovine adrenal medullary cells [2].
Antagonists of EP1 receptors (AH-6809 and SC-19920, 10 microM) and TP receptors (ICI-192605, 1 microM) had no effect on 8-iso-PGE2-induced augmentation of cholinergic responsiveness [3].
Thus, sulprostone, an EP1/EP3 agonist, displaced bound [3H]PGE2 and [3H]PGF2 alpha with IC50 of about 10(-7) M [4].
On the other hand, thromboxane antagonists (BAY u-3405 and GR-32191B), EP1 specific antagonist (SC-19220) EP1/DP antagonist (AH-6809) and iloprost, a stable prostacyclin agonist, failed to displace bound [3H]PGE2 or [3H]PGF2 alpha at a concentration range of 10(-9)-10(-6) M [4].

Anatomical context of EP1

OBJECTIVE: To visualize histochemically the prostaglandin EP1 receptor in human amnion cells and to study the effect of inflammatory cytokines, which are known to stimulate the EP1 receptor, on localization [5].
beta-penta-O-acetyl-D-galactopyranose stimulated succinate oxidation in intact liver mitochondria (100%), in broken mitochondria (50%) and in EP1 particles (20%), no effect was observed on purified succinic dehydrogenase [6].

Associations of EP1 with chemical compounds

Prostaglandin E2 induces Ca2+ release from ryanodine/caffeine-sensitive stores in bovine adrenal medullary cells via EP1-like receptors [2].
17-Phenyl-PGE2 (EP1 agonist), sulprostone and MB 28767 (15S-hydroxy-9-oxo-16-phenoxy-omega-tetranorprost-13E-enoic acid) (EP3 agonists) did not induce an increase in intracellular cyclic AMP at concentrations up to 10(-5)M [7].
In the feline iris-sphincter and in bovine and feline ciliary muscles, 17-phenyl trinor PGE2, an EP1 receptor agonist, significantly increased inositol phosphate turnover [8].

References

Prostaglandin E2-induced aldosterone release is mediated by an EP2 receptor. Csukas, S., Hanke, C.J., Rewolinski, D., Campbell, W.B. Hypertension (1998) [Pubmed]
Prostaglandin E2 induces Ca2+ release from ryanodine/caffeine-sensitive stores in bovine adrenal medullary cells via EP1-like receptors. Shibuya, I., Tanaka, K., Uezono, Y., Ueta, Y., Toyohira, Y., Yanagihara, N., Izumi, F., Yamashita, H. J. Neurochem. (1999) [Pubmed]
Augmentation of bovine airway smooth muscle responsiveness to carbachol, KCl, and histamine by the isoprostane 8-iso-PGE2. Catalli, A., Janssen, L.J. Am. J. Physiol. Lung Cell Mol. Physiol. (2004) [Pubmed]
A common low-affinity binding site for primary prostanoids on bovine aortic endothelial cells. Mazar-Feldman, J., Rimon, G. Cell. Signal. (1996) [Pubmed]
Immunohistochemical localization of the prostaglandin E subtype-1 receptor in cytokine-stimulated and unstimulated amnion cells. Gould, S.F., Spaziani, E.P., Benoit, R., O'Brien, W.F. Obstetrics and gynecology. (1999) [Pubmed]
Sugar derivatives and liver mitochondria. II. Effect of beta-penta-O-acetyl-D-galactopyranose. Chagas, G.M., Alvarez, M., Duarte, J.H., Campello, A.P., Voss, D.O. Res. Commun. Chem. Pathol. Pharmacol. (1979) [Pubmed]
Characterization of the PGE2 receptor subtype in bovine chondrocytes in culture. de Brum-Fernandes, A.J., Morisset, S., Bkaily, G., Patry, C. Br. J. Pharmacol. (1996) [Pubmed]
Generation second messengers by prostanoids in the iris-sphincter and ciliary muscles of cows, cats and humans. Bhattacherjee, P., Smithson, M., Paterson, C.A. Prostaglandins Leukot. Essent. Fatty Acids (1997) [Pubmed]

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PTGER1	Canis lupus familiaris
ptger1b	Danio rerio
ptger1a	Danio rerio
PTGER1	Homo sapiens
PTGER1	Macaca mulatta
Ptger1	Mus musculus
Ptger1	Rattus norvegicus

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