Disease relevance of Ptger1

• Prevention of diabetic nephropathy in rats by prostaglandin E receptor EP1-selective antagonist [1].
• CONCLUSION: Our finding that ONO-8711 significantly suppresses colonic ACF formation and cell proliferation strengthens the hypothesis that the selective prostaglandin E receptor EP1 antagonists possesses chemopreventive activity against colon cancer development [2].
• Prostaglandin E receptor EP3 subtype is involved in thermal hyperalgesia through its actions in the preoptic hypothalamus and the diagonal band of Broca in rats [3].
• Chemopreventive effects of ONO-8711, a selective prostaglandin E receptor EP(1) antagonist, on breast cancer development [4].
• Interleukin-1 beta-induced expression of the prostaglandin E-receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor-kappaB [5].

High impact information on Ptger1

• We previously reported that the activation of prostaglandin E receptor EP3 subtype caused neurite retraction via small GTPase Rho in the EP3B receptor-expressing PC12 cells (Katoh, H., Negishi, M., and Ichikawa, A. (1996) J. Biol. Chem. 271, 29780-29784) [6].
• Prostaglandin E receptor subtypes in cultured rat microglia and their role in reducing lipopolysaccharide-induced interleukin-1beta production [7].
• The medial POA has a high expression of prostaglandin E receptor subtype EP3 (EP3R) on POA neurons, suggesting that these EP3R are main central targets of PGE2 to mediate BAT thermogenesis [8].
• Neurons of the rat preoptic area and the raphe pallidus nucleus innervating the brown adipose tissue express the prostaglandin E receptor subtype EP3 [8].
• Is there more than one prostaglandin E receptor subtype mediating hyperalgesia in the rat hindpaw [9]?

Chemical compound and disease context of Ptger1

• Suppression of azoxymethane-induced colon cancer development in rats by a prostaglandin E receptor EP1-selective antagonist [10].

Biological context of Ptger1

• Expression of prostaglandin E receptor subtypes in bone: expression of EP2 in bone development [11].
• These results suggest the presence of more than one prostaglandin E-receptor subtype, which mediate hyperalgesia, predominantly via the cAMP second messenger system, in the hindpaw of the rat [9].
• Up-regulation of prostaglandin E receptor EP2 and EP4 subtypes in rat synovial tissues with adjuvant arthritis [12].
• In pithed rats, we studied the effects of prostaglandin E2 and of subtype-selective prostaglandin E receptor (EP receptor) ligands on the rise in blood pressure induced by electrical stimulation of the preganglionic sympathetic nerves [13].

Anatomical context of Ptger1

• Prostaglandin E receptor EP3 subtype induces neurite retraction via small GTPase Rho [14].
• Prostaglandin E receptor subtypes in smooth muscle: agonist activities of stable prostacyclin analogues [15].
• Membrane depolarization by activation of prostaglandin E receptor EP3 subtype of putative serotonergic neurons in the dorsal raphe nucleus of the rat [16].
• Effect of prostaglandin E receptor subtype EP4 selective agonist on the secretion of tumor necrosis factor-alpha by macrophages in acute ethanol-loaded rats [17].
• Differential expression of prostaglandin E receptor subtype EP2 in rat uterus during early pregnancy [18].

Associations of Ptger1 with chemical compounds

• We investigated the cyclooxygenase (COX) isoforms as well as prostaglandin E receptor EP subtypes responsible for acid-induced gastric HCO(3)(-) secretion in rats and EP receptor-knockout (-/-) mice [19].
• This study was designed to determine the chemopreventive effects of ONO-8711, a selective prostaglandin E receptor EP1 antagonist, on the development of azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) in male F344 rats and to compare its potential with that of nimesulide, a well-documented selective COX-2 inhibitor [2].
• The roles of prostaglandin E receptor subtypes in the cytoprotective action of prostaglandin E2 in rat stomach [20].
• Antinociceptive effect of spinally delivered prostaglandin E receptor antagonists in the formalin test on the rat [21].
• Variable responses were also observed between LO and CO MO in response to prostaglandin E2, indomethacin (INDO), and the prostaglandin E receptor antagonist SC-19220 [22].

Other interactions of Ptger1

• Regulation of the prostaglandin E receptor and the guanyl nucleotide regulatory subunit of hepatic adenylate cyclase [23].

Analytical, diagnostic and therapeutic context of Ptger1

• Molecular cloning and expression of rat prostaglandin E receptor EP2 subtype [24].

References