Gene Review:
PTGIR - prostaglandin I2 (prostacyclin) receptor (IP)
Homo sapiens
Synonyms:
IP, PGI receptor, PGI2 receptor, PRIPR, Prostacyclin receptor, ...
Arehart,
Schrör,
Paola Patrignani,
Concetta Di Febbo,
Stefania Tacconelli,
Karen Douville,
Maria D. Guglielmi,
Ryan J. Horvath,
Min Ding,
Kent Sierra,
Jeremiah Stitham,
Scott Gleim,
Giovanna Baccante,
Valeria Moretta,
Luigia Di Francesco,
Marta L. Capone,
Ettore Porreca,
John Hwa,
Hwa,
Breyer,
Grabensee,
Ruan,
Ruan,
Breyer,
Plum,
Stitham,
Breyer,
Wu,
Gleim,
Breyer,
Huang,
Meyer-Kirchrath,
Douville,
- Prostacyclin receptor induces STAT1 and STAT3 phosphorylations in human erythroleukemia cells: a mechanism requiring PTX-insensitive G proteins, ERK and JNK. Lo, R.K., Wise, H., Wong, Y.H. Cell. Signal. (2006)
- Human prostacyclin receptor structure and function from naturally-occurring and synthetic mutations. Stitham, J., Arehart, E.J., Gleim, S.R., Douville, K.L., Hwa, J. Prostaglandins Other Lipid Mediat. (2007)
- Impaired receptor binding and activation associated with a human prostacyclin receptor polymorphism. Stitham, J., Stojanovic, A., Hwa, J. J. Biol. Chem. (2002)
- Expression of prostanoid receptors in human ductus arteriosus. Leonhardt, A., Glaser, A., Wegmann, M., Schranz, D., Seyberth, H., Nüsing, R. Br. J. Pharmacol. (2003)
- Cardioprotective prostacyclin signaling in vascular smooth muscle. Fetalvero, K.M., Martin, K.A., Hwa, J. Prostaglandins Other Lipid Mediat. (2007)
- Differential association between human prostacyclin receptor polymorphisms and the development of venous thrombosis and intimal hyperplasia: a clinical biomarker study. Patrignani, P., Di Febbo, C., Tacconelli, S., Douville, K., Guglielmi, M.D., Horvath, R.J., Ding, M., Sierra, K., Stitham, J., Gleim, S., Baccante, G., Moretta, V., Di Francesco, L., Capone, M.L., Porreca, E., Hwa, J. Pharmacogenet. Genomics (2008)
- Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients. Stratton, R., Shiwen, X., Martini, G., Holmes, A., Leask, A., Haberberger, T., Martin, G.R., Black, C.M., Abraham, D. J. Clin. Invest. (2001)
- Central action of recombinant interleukin-1 to inhibit acid secretion in rats. Saperas, E.S., Yang, H., Rivier, C., Taché, Y. Gastroenterology (1990)
- G protein-coupled prostanoid receptors and the kidney. Breyer, M.D., Breyer, R.M. Annu. Rev. Physiol. (2001)
- The role of IP prostanoid receptors in inflammatory pain. Bley, K.R., Hunter, J.C., Eglen, R.M., Smith, J.A. Trends Pharmacol. Sci. (1998)
- Focus on prostacyclin and its novel mimetics. Wise, H., Jones, R.L. Trends Pharmacol. Sci. (1996)
- Pharmacological analysis of diisopropyl fluorophosphate: effects on core temperature, heart rate, and motor activity in the unrestrained rat. Gordon, C.J. Pharmacol. Biochem. Behav. (1996)
- Chromosomal localization of the human prostanoid receptor gene family. Duncan, A.M., Anderson, L.L., Funk, C.D., Abramovitz, M., Adam, M. Genomics (1995)
- The alpha, but not the beta, isoform of the human thromboxane A2 receptor is a target for prostacyclin-mediated desensitization. Walsh, M.T., Foley, J.F., Kinsella, B.T. J. Biol. Chem. (2000)
- Prostacyclin receptor up-regulates the expression of angiogenic genes in human endometrium via cross talk with epidermal growth factor Receptor and the extracellular signaling receptor kinase 1/2 pathway. Smith, O.P., Battersby, S., Sales, K.J., Critchley, H.O., Jabbour, H.N. Endocrinology (2006)
- The effect of the farnesyl protein transferase inhibitor SCH66336 on isoprenylation and signalling by the prostacyclin receptor. O'Meara, S.J., Kinsella, B.T. Biochem. J. (2005)
- Developmental regulation of prostacyclin synthase and prostacyclin receptors in the ovine uterus and conceptus during the peri-implantation period. Cammas, L., Reinaud, P., Bordas, N., Dubois, O., Germain, G., Charpigny, G. Reproduction (2006)
- Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system. Nakagawa, O., Tanaka, I., Usui, T., Harada, M., Sasaki, Y., Itoh, H., Yoshimasa, T., Namba, T., Narumiya, S., Nakao, K. Circulation (1994)
- Expression of prostacyclin receptor in human megakaryocytes. Sasaki, Y., Takahashi, T., Tanaka, I., Nakamura, K., Okuno, Y., Nakagawa, O., Narumiya, S., Nakao, K. Blood (1997)
- The effects of the statins lovastatin and cerivastatin on signalling by the prostanoid IP-receptor. Lawler, O.A., Miggin, S.M., Kinsella, B.T. Br. J. Pharmacol. (2001)
- Prostacyclin enhances the expression of LPS/INF-gamma-induced nitric oxide synthase in human monocytes. Plum, J., Huang, C., Grabensee, B., Schrör, K., Meyer-Kirchrath, J. Nephron (2002)
- Prostaglandin receptors: their role in regulating renal function. Breyer, M.D., Breyer, R.M. Curr. Opin. Nephrol. Hypertens. (2000)
- Induction of hyaluronic acid synthase 2 (HAS2) in human vascular smooth muscle cells by vasodilatory prostaglandins. Sussmann, M., Sarbia, M., Meyer-Kirchrath, J., Nüsing, R.M., Schrör, K., Fischer, J.W. Circ. Res. (2004)
- Distribution of prostaglandin IP and EP receptor subtypes and isoforms in platelets and human umbilical artery smooth muscle cells. Paul, B.Z., Ashby, B., Sheth, S.B. Br. J. Haematol. (1998)
- Functional characterization of the ocular prostaglandin f2alpha (PGF2alpha) receptor. Activation by the isoprostane, 12-iso-PGF2alpha. Kunapuli, P., Lawson, J.A., Rokach, J., FitzGerald, G.A. J. Biol. Chem. (1997)
- A strategy using NMR peptide structures of thromboxane A2 receptor as templates to construct ligand-recognition pocket of prostacyclin receptor. Ruan, C.H., Wu, J., Ruan, K.H. BMC Biochem. (2005)