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Gene Review

TBXA2R  -  thromboxane A2 receptor

Homo sapiens

Synonyms: BDPLT13, Prostanoid TP receptor, TXA2-R, Thromboxane A2 receptor
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Disease relevance of TBXA2R


High impact information on TBXA2R


Chemical compound and disease context of TBXA2R


Biological context of TBXA2R

  • TBXA2R was localized to chromosome 19 by PCR amplification in a series of monochoromosomal human/rodent somatic cell hybrids [14].
  • Transient expression of the HEL cell TXA2 receptor cDNA and radioligand binding studies with the agonist 125I-BOP showed a single class of binding sites with an affinity comparable to a low affinity platelet TXA2 receptor [15].
  • These findings may provide useful information for conducting mutagenesis and reveal the molecular mechanism how the human TXA2 receptor interact with G alpha 13 to activate intracellular signaling [16].
  • RESULTS: The genotype frequencies of IL-5 and TBXA2R polymorphisms did not differ between healthy controls and atopic or nonatopic children with asthma [17].
  • OBJECTIVE: To determine whether IL-5 (T-746C) and TBXA2R (T924C) gene polymorphisms are associated with asthma phenotype and pulmonary function in Korean children with atopic and nonatopic asthma [17].

Anatomical context of TBXA2R


Associations of TBXA2R with chemical compounds


Physical interactions of TBXA2R


Regulatory relationships of TBXA2R


Other interactions of TBXA2R


Analytical, diagnostic and therapeutic context of TBXA2R


  1. Synthetic peroxisome proliferator-activated receptor gamma agonists rosiglitazone and troglitazone suppress transcription by promoter 3 of the human thromboxane A2 receptor gene in human erythroleukemia cells. Coyle, A.T., Kinsella, B.T. Biochem. Pharmacol. (2006) [Pubmed]
  2. Expression of thromboxane synthase, TBXAS1 and the thromboxane A2 receptor, TBXA2R, in human breast cancer. Watkins, G., Douglas-Jones, A., Mansel, R.E., Jiang, W.G. International seminars in surgical oncology [electronic resource] : ISSO. (2005) [Pubmed]
  3. Cloning and pharmacologic characterization of a thromboxane A2 receptor from K562 (human chronic myelogenous leukemia) cells. D'Angelo, D.D., Davis, M.G., Ali, S., Dorn, G.W. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  4. Decrease in thromboxane A2 receptor expression by differentiation with dibutyryl cyclic AMP in 1321N1 human astrocytoma cells. Honma, S., Nakahata, N., Kobayashi, H., Ikeda, S., Takeda, N., Ohizumi, Y. Prostaglandins Other Lipid Mediat. (1999) [Pubmed]
  5. Bruton tyrosine kinase is essential for botrocetin/VWF-induced signaling and GPIb-dependent thrombus formation in vivo. Liu, J., Fitzgerald, M.E., Berndt, M.C., Jackson, C.W., Gartner, T.K. Blood (2006) [Pubmed]
  6. Cloning and expression of cDNA for a human thromboxane A2 receptor. Hirata, M., Hayashi, Y., Ushikubi, F., Yokota, Y., Kageyama, R., Nakanishi, S., Narumiya, S. Nature (1991) [Pubmed]
  7. Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation. Hirata, T., Ushikubi, F., Kakizuka, A., Okuma, M., Narumiya, S. J. Clin. Invest. (1996) [Pubmed]
  8. Thromboxane synthase inhibitors, thromboxane receptor antagonists and dual blockers in thrombotic disorders. Gresele, P., Deckmyn, H., Nenci, G.G., Vermylen, J. Trends Pharmacol. Sci. (1991) [Pubmed]
  9. Mechanism of platelet inhibition by nitric oxide: in vivo phosphorylation of thromboxane receptor by cyclic GMP-dependent protein kinase. Wang, G.R., Zhu, Y., Halushka, P.V., Lincoln, T.M., Mendelsohn, M.E. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  10. 15-deoxy Delta12,14-prostaglandin J2 suppresses transcription by promoter 3 of the human thromboxane A2 receptor gene through peroxisome proliferator-activated receptor gamma in human erythroleukemia cells. Coyle, A.T., O'Keeffe, M.B., Kinsella, B.T. FEBS J. (2005) [Pubmed]
  11. U46619-mediated vasoconstriction of the fetal placental vasculature in vitro in normal and hypertensive pregnancies. Read, M.A., Leitch, I.M., Giles, W.B., Bisits, A.M., Boura, A.L., Walters, W.A. J. Hypertens. (1999) [Pubmed]
  12. Involvement of phosphatidylcholine-specific phospholipase C in thromboxane A2-induced activation of mitogen-activated protein kinase in astrocytoma cells. Kobayashi, H., Honma, S., Nakahata, N., Ohizumi, Y. J. Neurochem. (2000) [Pubmed]
  13. Sepsis-associated renal vasoconstriction: potential targets for future therapy. Badr, K.F. Am. J. Kidney Dis. (1992) [Pubmed]
  14. Linkage mapping of the human thromboxane A2 receptor (TBXA2R) to chromosome 19p13.3 using transcribed 3' untranslated DNA sequence polymorphisms. Schwengel, D.A., Nouri, N., Meyers, D.A., Levitt, R.C. Genomics (1993) [Pubmed]
  15. Characterization of the cloned HEL cell thromboxane A2 receptor: evidence that the affinity state can be altered by G alpha 13 and G alpha q. Allan, C.J., Higashiura, K., Martin, M., Morinelli, T.A., Kurtz, D.T., Geoffroy, O., Meier, G.P., Gettys, T.W., Halushka, P.V. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  16. Coupling interaction between thromboxane A2 receptor and alpha-13 subunit of guanine nucleotide-binding protein. Chou, K.C. J. Proteome Res. (2005) [Pubmed]
  17. IL-5 and thromboxane A2 receptor gene polymorphisms are associated with decreased pulmonary function in Korean children with atopic asthma. Hong, S.J., Lee, S.Y., Kim, H.B., Kim, J.H., Kim, B.S., Choi, S.O., Lee, S.G., Shin, E.S., Hong, T.J. J. Allergy Clin. Immunol. (2005) [Pubmed]
  18. Identification of Galpha13 as one of the G-proteins that couple to human platelet thromboxane A2 receptors. Djellas, Y., Manganello, J.M., Antonakis, K., Le Breton, G.C. J. Biol. Chem. (1999) [Pubmed]
  19. Characterization of excitatory prostanoid receptors in the human umbilical artery in vitro. Boersma, J.I., Janzen, K.M., Oliveira, L., Crankshaw, D.J. Br. J. Pharmacol. (1999) [Pubmed]
  20. Thromboxane A2 receptor signaling inhibits vascular endothelial growth factor-induced endothelial cell differentiation and migration. Ashton, A.W., Ware, J.A. Circ. Res. (2004) [Pubmed]
  21. The effects of the statins lovastatin and cerivastatin on signalling by the prostanoid IP-receptor. Lawler, O.A., Miggin, S.M., Kinsella, B.T. Br. J. Pharmacol. (2001) [Pubmed]
  22. The alpha, but not the beta, isoform of the human thromboxane A2 receptor is a target for prostacyclin-mediated desensitization. Walsh, M.T., Foley, J.F., Kinsella, B.T. J. Biol. Chem. (2000) [Pubmed]
  23. The human thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha. Kinsella, B.T., O'Mahony, D.J., Fitzgerald, G.A. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  24. Galpha12 and galpha13 are phosphorylated during platelet activation. Offermanns, S., Hu, Y.H., Simon, M.I. J. Biol. Chem. (1996) [Pubmed]
  25. Two waves of platelet secretion induced by thromboxane A2 receptor and a critical role for phosphoinositide 3-kinases. Li, Z., Zhang, G., Le Breton, G.C., Gao, X., Malik, A.B., Du, X. J. Biol. Chem. (2003) [Pubmed]
  26. Genetic variants of the receptors for thromboxane A2 and IL-4 in atopic dermatitis. Tanaka, K., Roberts, M.H., Yamamoto, N., Sugiura, H., Uehara, M., Mao, X.Q., Shirakawa, T., Hopkin, J.M. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  27. The G protein coupled to the thromboxane A2 receptor in human platelets is a member of the novel Gq family. Shenker, A., Goldsmith, P., Unson, C.G., Spiegel, A.M. J. Biol. Chem. (1991) [Pubmed]
  28. Preferential involvement of a phospholipase A2-dependent pathway in CD69-mediated platelet activation. Testi, R., Pulcinelli, F.M., Cifone, M.G., Botti, D., Del Grosso, E., Riondino, S., Frati, L., Gazzaniga, P.P., Santoni, A. J. Immunol. (1992) [Pubmed]
  29. The thromboxane A2 receptor activates mitogen-activated protein kinase via protein kinase C-dependent Gi coupling and Src-dependent phosphorylation of the epidermal growth factor receptor. Gao, Y., Tang, S., Zhou, S., Ware, J.A. J. Pharmacol. Exp. Ther. (2001) [Pubmed]
  30. Glibenclamide inhibits thromboxane A2-induced contraction in human internal mammary artery and saphenous vein. Stanke, F., Cracowski, J.L., Chavanon, O., Magne, J.L., Blin, D., Bessard, G., Devillier, P. Eur. J. Pharmacol. (1998) [Pubmed]
  31. Reconstitution of thromboxane A2 receptor-stimulated phosphoinositide hydrolysis in isolated platelet membranes: involvement of phosphoinositide-specific phospholipase C-beta and GTP-binding protein Gq. Baldassare, J.J., Tarver, A.P., Henderson, P.A., Mackin, W.M., Sahagan, B., Fisher, G.J. Biochem. J. (1993) [Pubmed]
  32. Prevention of restenosis after percutaneous transluminal coronary angioplasty with thromboxane A2-receptor blockade. A randomized, double-blind, placebo-controlled trial. Coronary Artery Restenosis Prevention on Repeated Thromboxane-Antagonism Study (CARPORT). Serruys, P.W., Rutsch, W., Heyndrickx, G.R., Danchin, N., Mast, E.G., Wijns, W., Rensing, B.J., Vos, J., Stibbe, J. Circulation (1991) [Pubmed]
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