The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SENP7  -  SUMO1/sentrin specific peptidase 7

Homo sapiens

Synonyms: KIAA1707, SSP2, SUMO-1-specific protease 2, SUSP2, Sentrin-specific protease 7, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SENP7


High impact information on SENP7

  • Plasmodium falciparum sporozoite surface protein 2 (PfSSP2) is considered an important antigen for inclusion in such vaccines, because CD8+ CTL against the P. yoelii SSP2 protect mice against malaria by eliminating infected hepatocytes [2].
  • The model of protective immunity induced by immunization with irradiated plasmodia sporozoites (SPZ) has become the prototype for a promising vaccine strategy based on Ab and CTL responses directed against pre-erythrocytic stage Ags, in particular the circumsporozoite protein (CSP) and sporozoite surface protein 2 (SSP2) [3].
  • Furthermore, in vitro proteolytic cleavage of SSP-1 produces an SSP-2-like protein which coincides with a loss of adhesive function [1].
  • In normal tissue we found restricted and moderate reactivity with SSP2 in steroidogenic cells, chondrocytes, placental trophoblasts, vascular smooth muscle cells, and endothelial cells [4].

Associations of SENP7 with chemical compounds

  • TRAP or SSP2, found on the parasite surface and in micronemes, binds to hepatocytes in a similar pattern as CS protein [5].
  • Structure-guided mutational analysis reveals elements unique to the SENP6 and SENP7 subclass of SENP/ULP proteases that contribute to protease function during deconjugation of poly-SUMO chains [6].

Regulatory relationships of SENP7

  • SSP-1 expression is down-regulated in a phenotypical variant of S. epidermidis 354 whereas SSP-2 expression is not [1].

Analytical, diagnostic and therapeutic context of SENP7

  • Stigma-specific proteins associated with the S(1) allele and the S(2) allele have been identified using isoelectric focusing and these proteins have been designated SSP1 (Stigma S-associated Protein 1) and SSP2 [7].


  1. Ultrastructural organization and regulation of a biomaterial adhesin of Staphylococcus epidermidis. Veenstra, G.J., Cremers, F.F., van Dijk, H., Fleer, A. J. Bacteriol. (1996) [Pubmed]
  2. Irradiated sporozoite vaccine induces HLA-B8-restricted cytotoxic T lymphocyte responses against two overlapping epitopes of the Plasmodium falciparum sporozoite surface protein 2. Wizel, B., Houghten, R.A., Parker, K.C., Coligan, J.E., Church, P., Gordon, D.M., Ballou, W.R., Hoffman, S.L. J. Exp. Med. (1995) [Pubmed]
  3. T lymphocytes from volunteers immunized with irradiated Plasmodium falciparum sporozoites recognize liver and blood stage malaria antigens. Krzych, U., Lyon, J.A., Jareed, T., Schneider, I., Hollingdale, M.R., Gordon, D.M., Ballou, W.R. J. Immunol. (1995) [Pubmed]
  4. Distribution of SPARC in normal and neoplastic human tissue. Porter, P.L., Sage, E.H., Lane, T.F., Funk, S.E., Gown, A.M. J. Histochem. Cytochem. (1995) [Pubmed]
  5. The malaria sporozoite's journey into the liver. Sinnis, P. Infectious agents and disease. (1996) [Pubmed]
  6. Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7. Lima, C.D., Reverter, D. J. Biol. Chem. (2008) [Pubmed]
  7. Sporophytic self-incompatibility in Senecio squalidus L (Asteraceae)--the search for S. Hiscock, S.J., McInnis, S.M., Tabah, D.A., Henderson, C.A., Brennan, A.C. J. Exp. Bot. (2003) [Pubmed]
WikiGenes - Universities