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Gene Review:

VPS18 - vacuolar protein sorting 18 homolog (S....

Homo sapiens

Synonyms: KIAA1475, PEP3, Vacuolar protein sorting-associated protein 18 homolog, hVPS18

Kim, B.Y. et al., Yogosawa, S. et al., Yogosawa, S. et al.

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High impact information on VPS18

The half-life of SNK is increased in HeLa cells that down-regulated hVPS18 by lentivirus-mediated small hairpin RNA interference [1].
Furthermore, the delayed entry into S phase is observed in HeLa cells overexpressing hVPS18 [1].
The protein products of hVPS11 (hVps11) and hVPS18 (hVps18) were ubiquitously expressed in peripheral tissues, suggesting that they have a fundamental role in cellular function [2].
Monoubiquitylation of GGA3 by hVPS18 regulates its ubiquitin-binding ability [3].

Other interactions of VPS18

Using the yeast two-hybrid screening, we identify SNK as a candidate substrate of hVPS18 [1].

References

Ubiquitylation and degradation of serum-inducible kinase by hVPS18, a RING-H2 type ubiquitin ligase. Yogosawa, S., Hatakeyama, S., Nakayama, K.I., Miyoshi, H., Kohsaka, S., Akazawa, C. J. Biol. Chem. (2005) [Pubmed]
Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7. Kim, B.Y., Krämer, H., Yamamoto, A., Kominami, E., Kohsaka, S., Akazawa, C. J. Biol. Chem. (2001) [Pubmed]
Monoubiquitylation of GGA3 by hVPS18 regulates its ubiquitin-binding ability. Yogosawa, S., Kawasaki, M., Wakatsuki, S., Kominami, E., Shiba, Y., Nakayama, K., Kohsaka, S., Akazawa, C. Biochem. Biophys. Res. Commun. (2006) [Pubmed]

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AgaP_AGAP000983	Anopheles gambiae str. PEST
AT1G12470	Arabidopsis thaliana
VPS18	Bos taurus
VPS18	Canis lupus familiaris
vps18	Danio rerio
dor	Drosophila melanogaster
VPS18	Gallus gallus
VPS18	Macaca mulatta
MGG_06325	Magnaporthe oryzae 70-15
Vps18	Mus musculus
NCU06183	Neurospora crassa OR74A
Os08g0178100	Oryza sativa Japonica Group
VPS18	Pan troglodytes
Vps18	Rattus norvegicus
pep3	Schizosaccharomyces pombe 972h-
vps18	Xenopus (Silurana) tropicalis

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