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Gene Review

VPS11  -  vacuolar protein sorting 11 homolog (S....

Homo sapiens

Synonyms: END1, PEP5, PP3476, RING finger protein 108, RNF108, ...
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Disease relevance of VPS11

  • The peptides displayed by these phages were: pep1 = Ala-Asp-Gly-Gly-Ala-Gln-Gly-Thr-Ala; pep2 = Pro-Gly-Pro-Ser-Arg-Ala-His-Phe-Leu; pep3 = Leu-Ser-Ser-Arg-Glu-Pro-Gln-Ala-Arg; pep4 = Arg-Leu-Thr-Arg-Glu-Leu-Tyr-Ala-Gln and pep5 = Tyr-Thr-Gln-Lys-His-Gln-Ala [1].
  • Expression of "Ia-like" antigens on cells from a human endometrial carcinoma cell line, END-1 [2].
  • Our findings complement previous macroscale findings and are consistent with a cellular mechanism involving increased END1 and PDGFB levels, but decreased NOS3 levels, leading to intimal hyperplasia at regions of low magnitude reversing WSS [3].
  • CONCLUSIONS: Our results show that gender and the END1 gene modify the phenotypic expression of hypertrophy in patients with HCM [4].
  • The immunity mechanism of Pep5 in Staphylococcus epidermidis is based on inhibition of pore formation by a small 69-amino acid protein weakly associated with the outer surface of the cytoplasmic membrane [5].

High impact information on VPS11

  • The protein products of hVPS11 (hVps11) and hVPS18 (hVps18) were ubiquitously expressed in peripheral tissues, suggesting that they have a fundamental role in cellular function [6].
  • This study demonstrates altered receptor trafficking in End1 and End2 cell lines, a novel aspect of the mutant phenotypes [7].
  • The lines (VK2/E6E7, Ect1/E6E7, and End1/E6E7) displayed distinctive morphologies at the level of light microscopy when cultured in calcium-supplemented (0.4 mM) keratinocyte serum-free medium and maintained a stable phenotype after more than 1 yr of continuous passage [8].
  • The genotypes of AGT (M235T, T174M, and G-6A), AT1a, and END1 were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) or mutation-specific PCR (MS-PCR) [4].
  • Heterozygous polymorphisms in the VPS11 and DPAGT1 genes were found [9].

Biological context of VPS11

  • The END1 genotypes also had a significant influence on LVH scores accounting for 2.9% of their variability (p = 0.042) [4].
  • A cluster of pathogenicity genes ( PEP1, PEP2, PDA1, PEP5), termed the pea pathogenicity ( PEP) cluster and located on a 1.6-Mb conditionally dispensable (CD) chromosome, was identified in the fungal pathogen Nectria haematococca [10].

Associations of VPS11 with chemical compounds

  • They can be divided into unmodified peptides (e.g. lactococcins, lactacins, pediocins) and lanthionine-containing peptides (lantibiotics, e.g. nisin, epidermin, Pep5) [11].
  • Training increased muscle ATP (P less than 0.05) and glycogen (P less than 0.01) concentrations and decreased muscle lactate concentration (P less than 0.05) in the TL at END1 [12].


  1. Identification of new B cell epitopes in the sera of rheumatoid arthritis patients using a random nanopeptide phage library. Dybwad, A., Førre, O., Kjeldsen-Kragh, J., Natvig, J.B., Sioud, M. Eur. J. Immunol. (1993) [Pubmed]
  2. Expression of "Ia-like" antigens on cells from a human endometrial carcinoma cell line, END-1. Carrel, S., Gross, N., Heumann, D., Mach, J.P. Transplantation (1979) [Pubmed]
  3. Shear stress magnitude and directionality modulate growth factor gene expression in preconditioned vascular endothelial cells. Passerini, A.G., Milsted, A., Rittgers, S.E. J. Vasc. Surg. (2003) [Pubmed]
  4. Role of candidate modifier genes on the phenotypic expression of hypertrophy in patients with hypertrophic cardiomyopathy. Brugada, R., Kelsey, W., Lechin, M., Zhao, G., Yu, Q.T., Zoghbi, W., Quinones, M., Elstein, E., Omran, A., Rakowski, H., Wigle, D., Liew, C.C., Sole, M., Roberts, R., Marian, A.J. J. Investig. Med. (1997) [Pubmed]
  5. Immunity to lantibiotics. Saris, P.E., Immonen, T., Reis, M., Sahl, H.G. Antonie Van Leeuwenhoek (1996) [Pubmed]
  6. Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7. Kim, B.Y., Krämer, H., Yamamoto, A., Kominami, E., Kohsaka, S., Akazawa, C. J. Biol. Chem. (2001) [Pubmed]
  7. Slowed receptor trafficking in mutant CHO lines of the End1 and End2 complementation groups. Johnson, L.S., Presley, J.F., Park, J.C., McGraw, T.E. J. Cell. Physiol. (1994) [Pubmed]
  8. Generation of papillomavirus-immortalized cell lines from normal human ectocervical, endocervical, and vaginal epithelium that maintain expression of tissue-specific differentiation proteins. Fichorova, R.N., Rheinwald, J.G., Anderson, D.J. Biol. Reprod. (1997) [Pubmed]
  9. A large deletion on chromosome 11 in acute intermittent porphyria. Di Pierro, E., Besana, V., Moriondo, V., Brancaleoni, V., Tavazzi, D., Casalgrandi, G., Ventura, P., Rocchi, E., Cappellini, M.D. Blood Cells Mol. Dis. (2006) [Pubmed]
  10. Expression profiles of pea pathogenicity ( PEP) genes in vivo and in vitro, characterization of the flanking regions of the PEP cluster and evidence that the PEP cluster region resulted from horizontal gene transfer in the fungal pathogen Nectria haematococca. Liu, X., Inlow, M., VanEtten, H.D. Curr. Genet. (2003) [Pubmed]
  11. Gene-encoded antibiotics made in bacteria. Sahl, H.G. Ciba Found. Symp. (1994) [Pubmed]
  12. Influence of single-leg training on muscle metabolism and endurance during exercise with the trained limb and the untrained limb. Hardman, A.E., Williams, C., Boobis, L.H. Journal of sports sciences. (1987) [Pubmed]
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