Gene Review:
PLK2 - polo-like kinase 2
Homo sapiens
Synonyms:
PLK-2, Polo-like kinase 2, SNK, Serine/threonine-protein kinase PLK2, Serine/threonine-protein kinase SNK, ...
- Transcriptional silencing of Polo-like kinase 2 (SNK/PLK2) is a frequent event in B-cell malignancies. Syed, N., Smith, P., Sullivan, A., Spender, L.C., Dyer, M., Karran, L., O'Nions, J., Allday, M., Hoffmann, I., Crawford, D., Griffin, B., Farrell, P.J., Crook, T. Blood (2006)
- Epigenetic inactivation implies a tumor suppressor function in hematologic malignancies for Polo-like kinase 2 but not Polo-like kinase 3. Smith, P., Syed, N., Crook, T. Cell Cycle (2006)
- Polo-like kinase 1 (Plk1) inhibits p53 function by physical interaction and phosphorylation. Ando, K., Ozaki, T., Yamamoto, H., Furuya, K., Hosoda, M., Hayashi, S., Fukuzawa, M., Nakagawara, A. J. Biol. Chem. (2004)
- Induction of tetraploidy through loss of p53 and upregulation of Plk1 by human papillomavirus type-16 E6. Incassati, A., Patel, D., McCance, D.J. Oncogene (2006)
- The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity. Oshimori, N., Ohsugi, M., Yamamoto, T. Nat. Cell Biol. (2006)
- Effect of RNA silencing of polo-like kinase-1 (PLK1) on apoptosis and spindle formation in human cancer cells. Spänkuch-Schmitt, B., Bereiter-Hahn, J., Kaufmann, M., Strebhardt, K. J. Natl. Cancer Inst. (2002)
- Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells. Meraldi, P., Honda, R., Nigg, E.A. EMBO J. (2002)
- Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes. Lane, H.A., Nigg, E.A. J. Cell Biol. (1996)
- Down-regulation of Polo-like kinase 1 elevates drug sensitivity of breast cancer cells in vitro and in vivo. Spänkuch, B., Heim, S., Kurunci-Csacsko, E., Lindenau, C., Yuan, J., Kaufmann, M., Strebhardt, K. Cancer Res. (2006)
- Utilization of Drosophila eye to probe the functions of two mammalian serine/threonine kinases, Snk and HsHPK. Liu, M.A., Huang, A.M., Chou, C.K., Liaw, G.J., Wu, C.W. J. Biomed. Sci. (2001)
- Ubiquitylation and degradation of serum-inducible kinase by hVPS18, a RING-H2 type ubiquitin ligase. Yogosawa, S., Hatakeyama, S., Nakayama, K.I., Miyoshi, H., Kohsaka, S., Akazawa, C. J. Biol. Chem. (2005)
- Polo-like Kinases Inhibited by Wortmannin: LABELING SITE AND DOWNSTREAM EFFECTS. Liu, Y., Jiang, N., Wu, J., Dai, W., Rosenblum, J.S. J. Biol. Chem. (2007)
- Oncogenic effect of Polo-like kinase 1 expression in human gastric carcinomas. Jang, Y.J., Kim, Y.S., Kim, W.H. Int. J. Oncol. (2006)
- Polo-like kinases in the nervous system. Seeburg, D.P., Pak, D., Sheng, M. Oncogene (2005)
- Protective effect of FK506 against apoptosis of SH-SY5Y cells correlates with regulation of the serum inducible kinase gene. Muramoto, M., Yamazaki, T., Morikawa, N., Okitsu, O., Nagashima, T., Oe, T., Nishimura, S., Kita, Y. Biochem. Pharmacol. (2005)
- Screening of Domain-specific Target Proteins of Polo-like Kinase 1: Construction and Application of Centrosome/Kinetochore-specific Targeting Peptide. Ji, J.H., Jang, Y.J. J. Biochem. Mol. Biol. (2006)
- Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells. Burns, T.F., Fei, P., Scata, K.A., Dicker, D.T., El-Deiry, W.S. Mol. Cell. Biol. (2003)
- Influence of chk1 and plk1 silencing on radiation- or cisplatin-induced cytotoxicity in human malignant cells. Gao, Q., Huang, X., Tang, D., Cao, Y., Chen, G., Lu, Y., Zhuang, L., Wang, S., Xu, G., Zhou, J., Ma, D. Apoptosis (2006)
- Normal cells, but not cancer cells, survive severe Plk1 depletion. Liu, X., Lei, M., Erikson, R.L. Mol. Cell. Biol. (2006)
- Differential regulation of polo-like kinase 1, 2, 3, and 4 gene expression in mammalian cells and tissues. Winkles, J.A., Alberts, G.F. Oncogene (2005)
- Expression of polo-like kinase 1 (PLK1) protein predicts the survival of patients with gastric carcinoma. Kanaji, S., Saito, H., Tsujitani, S., Matsumoto, S., Tatebe, S., Kondo, A., Ozaki, M., Ito, H., Ikeguchi, M. Oncology (2006)
- Role of Plk2 (Snk) in mouse development and cell proliferation. Ma, S., Charron, J., Erikson, R.L. Mol. Cell. Biol. (2003)