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Gene Review

STIM2  -  stromal interaction molecule 2

Homo sapiens

Synonyms: KIAA1482, Stromal interaction molecule 2
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High impact information on STIM2

  • Independent of store depletion, STIM2 colocalizes with and blocks the function of a STIM1 EF-hand mutant that preexists in puncta and is constitutively coupled to activate SOCs [1].
  • The close STIM1 homologue, STIM2, inhibited SOCE when expressed alone but coexpressed with Orai1 caused substantial constitutive (store-independent) Ca(2+) entry [2].
  • We reveal that STIM2 is a powerful SOC inhibitor when expressed in HEK293, PC12, A7r5, and Jurkat T cells [1].
  • While STIM1 is expressed in both the ER and plasma membrane, STIM2 is expressed only intracellularly [1].
  • STIM2 is expressed ubiquitously in cell lines, and co-precipitates with STIM1 from cell lysates [3].

Biological context of STIM2


Anatomical context of STIM2

  • METHODS: To investigate the roles of the STIM homologues in SOC activation in airway myocytes, specific siRNA sequences were utilised to target and selectively suppress both STIM1 and STIM2 [4].

Other interactions of STIM2

  • Here, we monitored receptor-triggered Ca(2+) signals in cells transfected with siRNAs against 2,304 human signaling proteins, and we identified two proteins required for Ca(2+)-store-depletion-mediated Ca(2+) influx, STIM1 and STIM2 [6].

Analytical, diagnostic and therapeutic context of STIM2

  • Activation was by "maximal" voluntary effort or by transcutaneous tetanic electrical stimulation that induced an isometric torque equal to 60% (STIM 1) or 45% (STIM 2) of the voluntary isometric value [7].


  1. STIM2 is an inhibitor of STIM1-mediated store-operated Ca2+ Entry. Soboloff, J., Spassova, M.A., Hewavitharana, T., He, L.P., Xu, W., Johnstone, L.S., Dziadek, M.A., Gill, D.L. Curr. Biol. (2006) [Pubmed]
  2. Orai1 and STIM reconstitute store-operated calcium channel function. Soboloff, J., Spassova, M.A., Tang, X.D., Hewavitharana, T., Xu, W., Gill, D.L. J. Biol. Chem. (2006) [Pubmed]
  3. Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins. Williams, R.T., Manji, S.S., Parker, N.J., Hancock, M.S., Van Stekelenburg, L., Eid, J.P., Senior, P.V., Kazenwadel, J.S., Shandala, T., Saint, R., Smith, P.J., Dziadek, M.A. Biochem. J. (2001) [Pubmed]
  4. A key role for STIM1 in store operated calcium channel activation in airway smooth muscle. Peel, S.E., Liu, B., Hall, I.P. Respir. Res. (2006) [Pubmed]
  5. Reflexes in the shoulder muscles elicited from the human coracoacromial ligament. Diederichsen, L.P., Nørregaard, J., Krogsgaard, M., Fischer-Rasmussen, T., Dyhre-Poulsen, P. J. Orthop. Res. (2004) [Pubmed]
  6. STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx. Liou, J., Kim, M.L., Heo, W.D., Jones, J.T., Myers, J.W., Ferrell, J.E., Meyer, T. Curr. Biol. (2005) [Pubmed]
  7. Effect of voluntary vs. artificial activation on the relationship of muscle torque to speed. Dudley, G.A., Harris, R.T., Duvoisin, M.R., Hather, B.M., Buchanan, P. J. Appl. Physiol. (1990) [Pubmed]
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