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Gene Review

CHD8  -  chromodomain helicase DNA binding protein 8

Homo sapiens

Synonyms: ATP-dependent helicase CHD8, AUTS18, CHD-8, Chromodomain-helicase-DNA-binding protein 8, DUPLIN, ...
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High impact information on CHD8

  • Here, we show that the SNF2-like chromodomain helicase protein CHD8 interacts with the insulator binding protein CTCF [1].
  • Further, the lack of CHD8 affected CpG methylation and histone acetylation around the CTCF binding sites, adjacent to heterochromatin, of BRCA1 and c-myc genes [1].
  • Here we show that Duplin is expressed predominantly from early- to mid-stage mouse embryogenesis, and we describe the generation of mice deficient in Duplin [2].
  • Duplin(-/-) embryos manifest growth retardation from embryonic day 5.5 (E5.5) and developmental arrest accompanied by massive apoptosis at E7 [2].

Other interactions of CHD8

  • These findings provide insight into the role of CTCF-CHD8 complex in insulation and epigenetic regulation at active insulator sites [1].


  1. CTCF-dependent chromatin insulator is linked to epigenetic remodeling. Ishihara, K., Oshimura, M., Nakao, M. Mol. Cell (2006) [Pubmed]
  2. Early embryonic death in mice lacking the beta-catenin-binding protein Duplin. Nishiyama, M., Nakayama, K., Tsunematsu, R., Tsukiyama, T., Kikuchi, A., Nakayama, K.I. Mol. Cell. Biol. (2004) [Pubmed]
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