Disease relevance of Cdon

• Cdo functions at multiple points in the sonic hedgehog pathway, and cdo-deficient mice accurately model human holoprosencephaly [1].

High impact information on Cdon

• Activation of p38{alpha}/{beta} MAPK in myogenesis via binding of the scaffold protein JLP to the cell surface protein Cdo [2].
• CDO, a robo-related cell surface protein that mediates myogenic differentiation [3].
• CDO is expressed in proliferating and differentiating C2C12 myoblasts and in myoblast lines derived by treating 10T1/2 fibroblasts with 5-azacytidine, but not in parental 10T1/2 cells [3].
• CDO and MyoD are therefore involved in a positive feedback loop that is central to the inverse relationship between cell differentiation and transformation [3].
• CDO, another component of the machinery directing skeletal muscle induction and expansion, selectively activated skeletal muscle- but not cardiomyocyte-specific genes [4].

Biological context of Cdon

• It is proposed that CDO mediates, at least in part, the effects of cell-cell interactions between muscle precursors that are critical in myogenesis [3].
• The overlapping expression patterns of cdo and boc in vivo, combined with the promotion of myogenesis by CDO/BOC complexes in cultured cells, strongly suggests that these proteins play a role together in the determination, differentiation, or both, of numerous cell types during vertebrate embryogenesis [5].

Anatomical context of Cdon

• We report here that mice lacking CDO display delayed skeletal muscle development [6].

Other interactions of Cdon

• The Cdo gene is, in turn, a target of MyoD [6].

References