High impact information on Zfp318

• In the present study, we further showed that TZF-L, an alternative spliced variant of TZF, enhanced transactivation function of AR [1].
• A zinc finger protein TZF is a novel corepressor of androgen receptor [2].
• In addition, TZF was recruited into AR subnuclear foci after the treatment of dihydrotestosterone [2].
• RT-PCR analysis of the expression level of mRNAs for mouse TZF and TZF-L showed that both transcripts are highly expressed in testis and moderately in kidney and ovary [3].
• Analysis of the open reading frame of each cDNA indicated that TZF and TZF-L were polypeptides of 942 and 2025 amino acid residues, respectively, and the N-terminal 902 amino acids of TZF-L were identical to those of TZF [3].

Biological context of Zfp318

• Testicular zinc finger protein (TZF) has a zinc finger motif of the Cys2-His2 type and its transcript is expressed predominantly in mouse spermatogenic cells [3].
• The mouse TZF/TZF-L gene spanned >20 kb and consisted of 11 exons [3].
• These experiments suggest that TZF and TZF-L may act to control the gene activity during spermatogenesis [3].
• Using the fragment of TZF as a probe, we isolated the alternative splice variant form (TZF-L) from mouse testis cDNA library [3].

References