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Gene Review

fgfr3  -  fibroblast growth factor receptor 3

Danio rerio

Synonyms: FGFR-3, Fibroblast growth factor receptor 3, SO:0000704, fc27h01, wu:fc27h01
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High impact information on fgfr3

  • In the hindbrain, a differential expression of fgfr3 was detected at several levels of intensity, with the highest expression in the posterior rhombomere 1 that is morphologically distinct from the anterior part, which develops into the cerebellum [1].
  • Further, analysis of fgfr3 expression in mutants deficient in the formation of the midbrain-hindbrain boundary (MHB), noi(-/-) and ace(-/-), demonstrated that in the absence of Pax2.1 and FGF8 activity, the expression domains of FGFR3 expand into the MHB, tegmentum, cerebellum and optic tectum, which are the affected structures in these mutants [1].


  1. fgfr3 and regionalization of anterior neural tube in zebrafish. Sleptsova-Friedrich, I., Li, Y., Emelyanov, A., Ekker, M., Korzh, V., Ge, R. Mech. Dev. (2001) [Pubmed]
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