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Gene Review

Fgfr3  -  fibroblast growth factor receptor 3

Mus musculus

Synonyms: CD333, FGFR-3, FR3, Fgfr-3, Fibroblast growth factor receptor 3, ...
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Disease relevance of Fgfr3


Psychiatry related information on Fgfr3


High impact information on Fgfr3


Chemical compound and disease context of Fgfr3


Biological context of Fgfr3


Anatomical context of Fgfr3

  • This suggests that signaling through Fgfr3 both promotes and inhibits chondrocyte proliferation, depending on the time during development [1].
  • Using a novel micro-mechanical indentation protocol, it was shown that articular cartilage in the humeral head of 4-month-old Fgfr3(-/-) mice was less resistant to compressive force and less stiff than that of littermate controls [16].
  • Additionally, Fgfr3 may coordinate the growth and differentiation of chondrocytes with the growth and differentiation of osteoprogenitor cells by simultaneously modulating Bmp4 and patched expression in both growth plate cartilage and in the perichondrium [2].
  • Here we investigated the L5 spinal ganglion and the sciatic nerve of intact Fgfr3-deficient mice after nerve injury [17].
  • Quantification of sensory neurons in the L5 spinal ganglion revealed no significant differences between wild-type and Fgfr3-deficient mice [17].

Associations of Fgfr3 with chemical compounds


Regulatory relationships of Fgfr3


Other interactions of Fgfr3


Analytical, diagnostic and therapeutic context of Fgfr3


  1. A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos. Iwata, T., Chen, L., Li, C., Ovchinnikov, D.A., Behringer, R.R., Francomano, C.A., Deng, C.X. Hum. Mol. Genet. (2000) [Pubmed]
  2. Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3. Naski, M.C., Colvin, J.S., Coffin, J.D., Ornitz, D.M. Development (1998) [Pubmed]
  3. Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers. Jang, J.H., Shin, K.H., Park, J.G. Cancer Res. (2001) [Pubmed]
  4. Thyroid hormones regulate fibroblast growth factor receptor signaling during chondrogenesis. Barnard, J.C., Williams, A.J., Rabier, B., Chassande, O., Samarut, J., Cheng, S.Y., Bassett, J.H., Williams, G.R. Endocrinology (2005) [Pubmed]
  5. Expression of fibroblast growth factor receptor-3 (FGFR3), signal transducer and activator of transcription-1, and cyclin-dependent kinase inhibitor p21 during endochondral ossification: differential role of FGFR3 in skeletal development and fracture repair. Nakajima, A., Shimizu, S., Moriya, H., Yamazaki, M. Endocrinology (2003) [Pubmed]
  6. High-resolution mapping of tlt, a mouse mutant lacking otoconia. Ying, H.C., Hurlé, B., Wang, Y., Bohne, B.A., Wuerffel, M.K., Ornitz, D.M. Mamm. Genome (1999) [Pubmed]
  7. Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3. Colvin, J.S., Bohne, B.A., Harding, G.W., McEwen, D.G., Ornitz, D.M. Nat. Genet. (1996) [Pubmed]
  8. Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia. Naski, M.C., Wang, Q., Xu, J., Ornitz, D.M. Nat. Genet. (1996) [Pubmed]
  9. Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Deng, C., Wynshaw-Boris, A., Zhou, F., Kuo, A., Leder, P. Cell (1996) [Pubmed]
  10. Highly activated Fgfr3 with the K644M mutation causes prolonged survival in severe dwarf mice. Iwata, T., Li, C.L., Deng, C.X., Francomano, C.A. Hum. Mol. Genet. (2001) [Pubmed]
  11. Apoptosis of granulosa cells and female infertility in achondroplastic mice expressing mutant fibroblast growth factor receptor 3G374R. Amsterdam, A., Kannan, K., Givol, D., Yoshida, Y., Tajima, K., Dantes, A. Mol. Endocrinol. (2001) [Pubmed]
  12. The IIIc alternative of Fgfr2 is a positive regulator of bone formation. Eswarakumar, V.P., Monsonego-Ornan, E., Pines, M., Antonopoulou, I., Morriss-Kay, G.M., Lonai, P. Development (2002) [Pubmed]
  13. FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung. Weinstein, M., Xu, X., Ohyama, K., Deng, C.X. Development (1998) [Pubmed]
  14. Stat1 controls postnatal bone formation by regulating fibroblast growth factor signaling in osteoblasts. Xiao, L., Naganawa, T., Obugunde, E., Gronowicz, G., Ornitz, D.M., Coffin, J.D., Hurley, M.M. J. Biol. Chem. (2004) [Pubmed]
  15. Unique expression pattern of the FGF receptor 3 gene during mouse organogenesis. Peters, K., Ornitz, D., Werner, S., Williams, L. Dev. Biol. (1993) [Pubmed]
  16. Defects in articular cartilage metabolism and early arthritis in fibroblast growth factor receptor 3 deficient mice. Valverde-Franco, G., Binette, J.S., Li, W., Wang, H., Chai, S., Laflamme, F., Tran-Khanh, N., Quenneville, E., Meijers, T., Poole, A.R., Mort, J.S., Buschmann, M.D., Henderson, J.E. Hum. Mol. Genet. (2006) [Pubmed]
  17. Fibroblast growth factor receptor 3 signaling regulates injury-related effects in the peripheral nervous system. Jungnickel, J., Gransalke, K., Timmer, M., Grothe, C. Mol. Cell. Neurosci. (2004) [Pubmed]
  18. Fibroblast growth factor (FGF)-2 and FGF receptor 3 are required for the development of the substantia nigra, and FGF-2 plays a crucial role for the rescue of dopaminergic neurons after 6-hydroxydopamine lesion. Timmer, M., Cesnulevicius, K., Winkler, C., Kolb, J., Lipokatic-Takacs, E., Jungnickel, J., Grothe, C. J. Neurosci. (2007) [Pubmed]
  19. Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation. Hart, K.C., Robertson, S.C., Donoghue, D.J. Mol. Biol. Cell (2001) [Pubmed]
  20. The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3. Agazie, Y.M., Movilla, N., Ischenko, I., Hayman, M.J. Oncogene (2003) [Pubmed]
  21. Identification of fibroblast growth factor 9 (FGF9) as a high affinity, heparin dependent ligand for FGF receptors 3 and 2 but not for FGF receptors 1 and 4. Hecht, D., Zimmerman, N., Bedford, M., Avivi, A., Yayon, A. Growth Factors (1995) [Pubmed]
  22. Overexpression of the myeloma-associated oncogene fibroblast growth factor receptor 3 confers dexamethasone resistance. Pollett, J.B., Trudel, S., Stern, D., Li, Z.H., Stewart, A.K. Blood (2002) [Pubmed]
  23. A Ser(365)-->Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasia. Chen, L., Li, C., Qiao, W., Xu, X., Deng, C. Hum. Mol. Genet. (2001) [Pubmed]
  24. Differential regulation of endochondral bone growth and joint development by FGFR1 and FGFR3 tyrosine kinase domains. Wang, Q., Green, R.P., Zhao, G., Ornitz, D.M. Development (2001) [Pubmed]
  25. Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway. Yasoda, A., Komatsu, Y., Chusho, H., Miyazawa, T., Ozasa, A., Miura, M., Kurihara, T., Rogi, T., Tanaka, S., Suda, M., Tamura, N., Ogawa, Y., Nakao, K. Nat. Med. (2004) [Pubmed]
  26. Signalling by fibroblast growth factor receptor 3 and parathyroid hormone-related peptide coordinate cartilage and bone development. Amizuka, N., Davidson, D., Liu, H., Valverde-Franco, G., Chai, S., Maeda, T., Ozawa, H., Hammond, V., Ornitz, D.M., Goltzman, D., Henderson, J.E. Bone (2004) [Pubmed]
  27. Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18. Liu, Z., Xu, J., Colvin, J.S., Ornitz, D.M. Genes Dev. (2002) [Pubmed]
  28. Expression of Fgf receptors 1, 2, and 3 in the developing mid- and hindbrain of the mouse. Blak, A.A., Naserke, T., Weisenhorn, D.M., Prakash, N., Partanen, J., Wurst, W. Dev. Dyn. (2005) [Pubmed]
  29. Fibroblast growth factor signaling regulates Dach1 expression during skeletal development. Horner, A., Shum, L., Ayres, J.A., Nonaka, K., Nuckolls, G.H. Dev. Dyn. (2002) [Pubmed]
  30. A novel form of FGF receptor-3 using an alternative exon in the immunoglobulin domain III. Avivi, A., Yayon, A., Givol, D. FEBS Lett. (1993) [Pubmed]
  31. Genomic organization of the human fibroblast growth factor receptor 3 (FGFR3) gene and comparative sequence analysis with the mouse Fgfr3 gene. Perez-Castro, A.V., Wilson, J., Altherr, M.R. Genomics (1997) [Pubmed]
  32. Mouse models orthologous to FGFR3-related skeletal dysplasias. Brodie, S.G., Deng, C.X. Pediatric pathology & molecular medicine. (2003) [Pubmed]
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