Disease relevance of FGFR3

• The related fibroblast growth factor receptors CEK 2 and 3 were preferentially expressed in the nerve ganglion and in the vestibular sensory epithelium, respectively [1].

High impact information on FGFR3

• We undertook a study of FGFR3 in the developing and mature chicken inner ear and during regeneration of this epithelium to determine whether FGFR3 shows a similar pattern of expression in birds [2].
• These results indicate that FGFR3 expression changes after drug-induced hair cell damage to the basilar papilla in an opposite way to that found in the mammalian cochlea and may be involved in regulating the proliferation of support cells [2].
• In the initial stages of hair cell regeneration, the support cells that reenter the mitotic cycle in the basilar papilla do not express detectable levels of FGFR3 mRNA [2].
• Several studies suggest fibroblast growth factor receptor 3 (FGFR3) plays a role in the development of the auditory epithelium in mammals [2].
• FGFR3 expression during development and regeneration of the chick inner ear sensory epithelia [2].

Biological context of FGFR3

• Gentamicin treatment sufficient to destroy hair cells in the basilar papilla causes a rapid, transient downregulation of FGFR3 mRNA in the region of damage [2].

Anatomical context of FGFR3

• Expression of FGFR3 was observed rather ubiquitously over mesoderm of limb and feather buds [3].
• FGFR3 is also expressed in anterior midbrain and hindbrain during this developmental period, and is additionally expressed in the posterior telencephalon, in the pretectum, and at the zona limitans intrathalamica [4].
• Expression of FGFR1, FGFR2 and FGFR3 during early neural development in the chick embryo [4].
• Here we show the expression patterns of three FGF receptors, (FGFR1, FGFR2 and FGFR3) in embryonic stages between gastrulation and limb bud formation, focussing particularly on neural tissues [4].
• During early neuromere formation FGFR1 transcripts are present throughout the neural tube, while transcripts for FGFR2 and FGFR3 become restricted to regions of the diencephalon and spinal cord [4].

Other interactions of FGFR3

• A little later, FGFR2 and FGFR3 are additionally expressed in the anterior midbrain and within the hindbrain [4].
• FGFR3 was expressed in all the chondrocyte types, yet strongly increased in the LS, USC, USP, and Ti in that order according to the concentration of FGF2 [5].

References