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Gene Review:

Hand2 - heart and neural crest derivatives...

Rattus norvegicus

Synonyms: Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2, Dhand, Heart-and neural crest derivatives-expressed protein 2, dHAND

Zang, M.X. et al., Poizat, C. et al.

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High impact information on Hand2

Here we show that exposure of cultured cardiomyocytes to doxorubicin resulted in the rapid depletion of transcripts for MEF2C, dHAND, and NKX2.5, three pivotal regulators of cardiac gene expression [1].
Cooperative interaction between the basic helix-loop-helix transcription factor dHAND and myocyte enhancer factor 2C regulates myocardial gene expression [2].
Cardiac-restricted transcription factors dHAND and myocyte enhancer factor 2C are expressed in the developing heart and activate several cardiac promoters [2].
In addition, dHAND and myocyte enhancer factor 2C interact to synergistically activate atrial natriuretic peptide and alpha-myosin heavy chain transcription [2].

Biological context of Hand2

To elucidate their exact regulatory functions, we have developed an RNA interference strategy to specifically inhibit dHAND and myocyte enhancer factor 2C protein production in H9c2 cells, which are derived from rat embryonic heart [2].

Associations of Hand2 with chemical compounds

Furthermore, chromatin immunoprecipitation analysis in H9c2 cells treated with phenylephrine showed that dHAND and myocyte enhancer factor 2C protein complex bind to the A/T sequence on atrial natriuretic peptide promoter [2].

Other interactions of Hand2

Consistent with these, expression of atrial natriuretic peptide and alpha-myosin heavy chain was up-regulated in H9c2 cells, which overexpressed dHAND and myocyte enhancer factor 2C [2].

References

Proteasome-mediated degradation of the coactivator p300 impairs cardiac transcription. Poizat, C., Sartorelli, V., Chung, G., Kloner, R.A., Kedes, L. Mol. Cell. Biol. (2000) [Pubmed]
Cooperative interaction between the basic helix-loop-helix transcription factor dHAND and myocyte enhancer factor 2C regulates myocardial gene expression. Zang, M.X., Li, Y., Wang, H., Wang, J.B., Jia, H.T. J. Biol. Chem. (2004) [Pubmed]

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