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Gene Review:

PCYT2 - phosphate cytidylyltransferase 2,...

Homo sapiens

Synonyms: CTP:phosphoethanolamine cytidylyltransferase, ET, Ethanolamine-phosphate cytidylyltransferase, Phosphorylethanolamine transferase

Poloumienko, A. et al., Johnson, C.M. et al., Nakashima, A. et al., Visedo-Gonzalez, E. et al., Bladergroen, B.A. et al.

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Disease relevance of PCYT2

CTP: phosphoethanolamine cytidylyltransferase (Pcyt2) promoter was isolated from human breast cancer MCF-7 cells and its activity delineated by luciferase reporter assays and gel-shift analysis [1].

High impact information on PCYT2

CTP-phosphoethanolamine cytidylyltransferase (ET) is the enzyme that catalyzes the formation of CDP-ethanolamine in the phosphatidylethanolamine biosynthetic pathway from ethanolamine [2].
2-Aminoethylarsonic acid as an analogue of ethanolamine phosphate. Endowment of ethanolamine-phosphate cytidylyltransferase with CTP pyrophosphatase activity [3].
Mouse and human proteins also differ in amino acid composition at the C-terminus due to an additional splicing between Exons 13 and 14 in PCYT2.The 5' RACE analyses and subsequent cloning of the promoter regions demonstrated that the mPcyt2 and PCYT2 promoters are located immediately upstream of the first exon [4].
In THP-1 and U937 cells, PCYT2 expression could vary with the stage of cell differentiation [4].
CTP: ethanolaminephosphate cytidylyltransferase (Pcyt2) is an important regulatory enzyme in phosphatidylethanolamine and plasmalogen biosynthesis [4].

Associations of PCYT2 with chemical compounds

CTP:phosphoethanolamine cytidylyltransferase (ET) catalyzes the conversion of phosphoethanolamine into CDP-ethanolamine [5].

References

Characterization of transcription factors and cis-acting elements that regulate human CTP: phosphoethanolamine cytidylyltransferase (Pcyt2). Johnson, C.M., Yuan, Z., Bakovic, M. Biochim. Biophys. Acta (2005) [Pubmed]
Cloning of a human cDNA for CTP-phosphoethanolamine cytidylyltransferase by complementation in vivo of a yeast mutant. Nakashima, A., Hosaka, K., Nikawa, J. J. Biol. Chem. (1997) [Pubmed]
2-Aminoethylarsonic acid as an analogue of ethanolamine phosphate. Endowment of ethanolamine-phosphate cytidylyltransferase with CTP pyrophosphatase activity. Visedo-Gonzalez, E., Dixon, H.B. Biochem. J. (1989) [Pubmed]
Genomic organization and differential splicing of the mouse and human Pcyt2 genes. Poloumienko, A., Coté, A., Quee, A.T., Zhu, L., Bakovic, M. Gene (2004) [Pubmed]
CTP:phosphoethanolamine cytidylyltransferase. Bladergroen, B.A., van Golde, L.M. Biochim. Biophys. Acta (1997) [Pubmed]

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AgaP_AGAP009264	Anopheles gambiae str. PEST
PECT1	Arabidopsis thaliana
PCYT2	Bos taurus
Y37E3.11	Caenorhabditis elegans
PCYT2	Canis lupus familiaris
pcyt2	Danio rerio
Pect	Drosophila melanogaster
MGG_00943	Magnaporthe oryzae 70-15
Pcyt2	Mus musculus
NCU04289	Neurospora crassa OR74A
Os12g0121300	Oryza sativa Japonica Group
PCYT2	Pan troglodytes
Pcyt2	Rattus norvegicus
SPAC15E1.05c	Schizosaccharomyces pombe 972h-
pcyt2	Xenopus (Silurana) tropicalis

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