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Gene Review

MS4A7  -  membrane-spanning 4-domains, subfamily A,...

Homo sapiens

Synonyms: 4SPAN2, CD20 antigen-like 4, CD20/FC-epsilon-RI-beta family member 4, CD20L4, CFFM4, ...
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Disease relevance of MS4A7


High impact information on MS4A7

  • Another distinct characteristic is that CFFM4 mRNA expression is not limited to the hematopoietic lineage [1].
  • The CFFM4 gene contains seven exons and six introns and is transcribed into an mRNA encoding a 240-amino acid protein with four hydrophobic regions [1].
  • However, the CFFM4 protein can be distinguished from the other members of the family based on the length of the second extracellular loop and the absence of an immunoreceptor tyrosine-based activation motif signal [1].
  • Such results indicate that CFFM4 is associated with mature cellular function in the monocytic lineage and like CD20 and FcepsilonRIbeta, it may be a component of a receptor complex involved in signal transduction [1].


  1. CFFM4: a new member of the CD20/FcepsilonRIbeta family. Gingras, M.C., Lapillonne, H., Margolin, J.F. Immunogenetics (2001) [Pubmed]
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